Gene expression and prognosis of sirtuin family members in ovarian cancer.
Gene expression and prognosis of sirtuin family members in ovarian cancer.
复制标题
卵巢癌中sirtuin家族成员的基因表达和预后。
DOI：
10.1097/md.0000000000020685
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Jiang Y
中科院分区：
文献类型：
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作者：
Zeng Z;Huang Y;Li Y;Huang S;Wang J;Tang Y;Jiang Y
Sirtuins（SIRTs）是一类依赖于烟酰胺腺嘌呤二核苷酸（NAD+）的脱乙酰酶，通过调节肿瘤代谢参与多种恶性肿瘤的发生和发展。然而，SIRTs在卵巢癌（OC）中的表达谱和预后作用仍不清楚。我们使用在线数据库强调SIRTs在OC患者中的转录表达和预后意义。应用基因表达谱交互分析（GEPIA）分析mRNA表达，Kaplan-Meier逐步回归法评价预后价值。在OC患者中，SIRT1/2/3显著下调，而其余SIRTs无显著变化。SIRT2/5/6/7高表达与良好的总生存期（OS）相关，而SIRT1/4高表达与较差的OS相关。此外，SIRTs mRNA水平异常与不同临床病理特征的OC患者的预后相关。这是第一项整合生物信息学方法的研究，旨在确定SIRT在OC中的表达谱和预后价值。提示SIRTs与OC的预后有关，可能成为OC潜在的治疗手段。
Sirtuins (SIRTs), a class of nicotinamide-adenine dinucleotide (NAD)+-dependent deacetylases, involve in modulating carcinogenesis and progression of various malignancies through their regulation of the cancer metabolism. However, the expression profiles and prognostic roles of SIRTs in ovarian cancer (OC) remain unclear. We underscore the transcriptional expression and prognostic significance of SIRTs in OC patients using online databases. Gene Expression Profiling Interactive analysis (GEPIA) was applied to analyze mRNA expression, and Kaplan–Meier plotter was used to evaluate prognostic value. In patients with OC, SIRT1/2/3 were significantly down-regulated, while rest of SIRTs were not significantly changed. High SIRT2/5/6/7 expression was correlated with favorable overall survival (OS), while high SIRT1/4 expression was correlated with poor OS. Additionally, aberrant SIRTs mRNA levels were related to the prognosis of OC patients with different clinicopathological characteristics. This is the first study to integrate bioinformatics approaches intended to identify the expression profiles and prognostic value of SIRTs in OC. These results suggest that SIRTs is related to the prognosis of OC and may be the potential therapeutic interventions in OC.