Occurrence, severity, and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer
Occurrence, severity, and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer
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DOI：
10.1016/j.jpainsymman.2005.04.012
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发表时间：
2005-11-01
影响因子：
4.7
通讯作者：
Okunieff, P
中科院分区：
文献类型：
--
作者：
Hickok, JT;Morrow, GR;Okunieff, P
很少有人知道的频率，严重程度和接受放射治疗（RT）的患者所经历的症状的过程。在这项描述性研究中，1129名患有各种癌症的患者在RT开始时完成了12项症状量表（SI）;其中419名患者还在另外4周内每周完成SI（5个数据点）。1129名患者中有84%在治疗开始时已经出现症状。在典型的5周RT过程中，所有症状的频率均显著增加（所有P < 0.001）。皮肤问题的增长幅度最大。最常见的症状（疲劳、嗜睡和睡眠问题）也是最严重的。女性患者和小于中位年龄（59岁）的患者报告的症状明显多于男性和59岁或以上的患者。症状频率和严重程度因癌症诊断而显着不同。对辐射诱导毒性的时间进程和剂量反应的更好理解将允许在获得患者同意时更准确地呈现副作用风险。
Little is known about the frequency, severity, and course of symptoms experienced by patients receiving radiotherapy (RT). For this descriptive study, 1129 patients with a variety of cancer diagnoses completed a 12-item Symptom Inventory (SI) at the start of RT; 419 of these patients also completed the SI weekly for an additional 4 weeks (five data points). Eighty-four percent of the 1129 patients were already experiencing symptoms when treatment began. All symptoms significantly increased infrequency over a typical 5 week RT course (all Ps < 0.001). Skin problems showed the largest increase. The most common symptoms (fatigue, drowsiness, and sleep problems) were also the most severe. Female patients and patients younger than the median age (59 years) reported significantly more symptoms than males and those 59 years or older. Symptom frequency and severity varied significantly by cancer diagnosis. Improved understanding about the time course and dose response of radiation-induced toxicity will permit more accurate Presentation of side effect risk at the time patient consent is obtained.