A QUANTITATIVE-GENETIC ANALYSIS OF HIPPOCAMPAL VARIATION IN THE MOUSE
A QUANTITATIVE-GENETIC ANALYSIS OF HIPPOCAMPAL VARIATION IN THE MOUSE
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DOI：
10.3109/01677068609106850
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发表时间：
1986-07-01
影响因子：
1.9
通讯作者：
SCHWEGLER, H
中科院分区：
文献类型：
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作者：
CRUSIO, WE;GENTHNERGRIMM, G;SCHWEGLER, H
这份报告分析了小鼠中隔-颞叶水平的海马区终末野比例的遗传基础。我们使用了5个自交系和它们之间所有可能的F1杂交(双列杂交)。广义遗传力在11%到53%之间。所分析的所有表型均存在加性遗传变异。只有翼上苔藓纤维终端野的相对大小具有方向性优势。对于腔隙分子层，出现了双向优势。这些发现表明，在进化史上，定向选择的作用范围相当大。对于所有其他海马区变量(即推测了稳定选择前岩层、锥体、放射体、腔隙分子、CA4、锥体内和锥体下苔藓纤维终末的相对大小以及下区的绝对大小。
This report analyses the genetic underpinnings of the proportions of the hippocampal terminal fields in the mouse at the midseptotemporal level. We used 5 inbred strains and all possible F1 crosses between them (diallel cross). Broad heritabilities ranged from 11 to 53%. Additive genetic variation was present for all phenotypes analyzed. Directional dominance was found for the relative size of the suprapyramidal mossy fiber terminal field only. For the stratum lacunosum-moleculare, ambidirectional dominance emerged. These findings suggest that, in evolutionary history, directional selection has operated for a proportionally large suprapyramidal terminal field. For all other hippocampal variables (viz. the relative sizes for the strata oriens, pyramidale, radiatum, lacurosum-moleculare, CA4, intra- and infrapyramidal mossy fiber terminal field and the absolute size of the regio inferior) past stabilizing selection was inferred.