Response to an adequate dietary intake of vitamin D3 modulates the effect of estrogen therapy on bone density.
Response to an adequate dietary intake of vitamin D3 modulates the effect of estrogen therapy on bone density.
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饮食中摄入足够的维生素 D3 可以调节雌激素治疗对骨密度的影响。
DOI：
10.1089/jwh.2011.3244
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Appt,SusanE
中科院分区：
文献类型：
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作者：
Schnatz,PeterF;Marakovits,KimberlyA;O'Sullivan,DavidM;Ethun,Kelly;Clarkson,ThomasB;Appt,SusanE
前言：本研究分析了血浆25-羟基维生素D3（25OHD3）与骨密度（BMD）的关系，以及共轭马雌激素（CEE）对BMD的影响是否受到25OHD3的调节。方法：50只食蟹猴被喂食含有维生素D3的饮食（提供相当于1000 IU/天的女性维生素D3）。这些猴子接受了双侧卵巢切除术，随机分配到CEE（相当于0.45毫克/天）（n=25）或安慰剂（n=25），并继续接受相同的饮食。在随机分组时和6个月后分别测量25ohd3和BMD。在20个月（相当于人类6年）后测量骨密度。随后分析了25ohd3与骨密度之间的关系。结果：25ohd3基线血药浓度变化范围为26 ~ 95 ng/mL（平均±标准差[SD] 54±15 ng/mL）。较高的25ohd3血浆浓度与显著增加的骨密度相关。服用CEE和安慰剂的猴子在20个月内骨密度增加；但二者增幅无显著差异（0.034 g/cm2vs）。0.020 g/cm2;p=0.064)。25ohd3浓度较高与较低患者的20个月骨密度在CEE治疗后显著增加（p=0.027）。在25 ohd3浓度较高和较低的患者中，20个月的骨密度变化百分比在CEE治疗后也显著增加（p=0.018）。在接受安慰剂的患者中，较高的25ohd3浓度对骨密度没有显著影响。结论：给猴子喂食含有1000 IU/天的25ohd3的食物，其血浆中25ohd3的浓度范围很广。25ohd3浓度较高的CEE患者BMD较高，提示25ohd3和CEE对BMD具有协同作用。
Introduction:This study analyzed associations between plasma 25-hydroxyvitamin D3(25OHD3) and bone mineral density (BMD) and whether the effects of conjugated equine estrogens (CEE) on BMD are modulated by 25OHD3.Methods:Fifty cynomolgus monkeys were fed a diet containing vitamin D3(providing a woman's equivalent of 1000 IU/day of vitamin D3). The monkeys underwent bilateral oophorectomy and were randomized to either CEE (equivalent of 0.45 mg/day) (n=25) or placebo (n=25) and continued receiving the same diet. 25OHD3and BMD were measured at randomization and after 6 months. BMD also was measured after 20 months (equivalent to 6 human years). Associations between 25OHD3and BMD were subsequently analyzed.Results:Baseline 25OHD3plasma concentrations varied from 26 to 95 ng/mL (mean±standard deviation [SD] 54 ± 15 ng/mL). Higher plasma concentrations of 25OHD3were associated with a significantly increased BMD. Monkeys on both CEE and placebo had increased BMD over 20 months; however, the increase was not significantly different (0.034 g/cm2vs. 0.020 g/cm2, respectively;p=0.064). The 20-month BMD increased significantly with CEE treatment in those with higher vs. lower 25OHD3concentrations (p=0.027). The percent change in BMD over 20 months also increased significantly with CEE treatment in those with higher vs. lower 25OHD3concentrations (p=0.018). A higher 25OHD3concentration had no significant effect on BMD in those receiving placebo.Conclusions:Monkeys fed a diet containing 1000 IU/day equivalent of 25OHD3have a wide range of plasma 25OHD3concentrations. Those receiving CEE with higher 25OHD3concentrations had higher BMDs, suggesting 25OHD3and CEE have synergistic effects on BMD.