Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice.
Acetylcholine and an acetylcholinesterase inhibitor neostigmine can aggravate tularemia progress in BALB/c mice.
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DOI：
10.2478/v10102-012-0004-7
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发表时间：
2012-03
影响因子：
--
通讯作者：
Pikula J
中科院分区：
文献类型：
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作者：
Pohanka M;Pavlis O;Svobodova H;Pikula J
本实验旨在评估乙酰胆碱酯酶（AChE）伪不可逆抑制剂新斯的明和神经递质乙酰胆碱（ACh）的应用。这项实验是为了评估它们调节一种传染病——土拉菌病的能力。与仅暴露于生理盐水溶液的感染小鼠相比，感染土拉菌弗朗西斯菌并暴露于乙酰胆碱或新斯的明的小鼠死亡率和脾脏细菌负荷更高。激活的胆碱能抗炎途径抑制了兔热病解决所必需的途径。给患有兔热病的个体服用乙酰胆碱酯酶抑制剂是禁忌症。当怀疑兔热病或有类似发病机制的疾病时，应限制基于乙酰胆碱酯酶抑制的药物。
The present experiment was aimed at assessing the application of neostigmine, an acetylcholinesterase (AChE) pseudo-irreversible inhibitor with poor penetration through the hematoencephalitic barrier, and the neurotransmitter acetylcholine (ACh). The experiment was done to evaluate their ability to modulate an infectious disease: tularemia. Mice infected with Franciselle tularensis and exposed to either ACh or neostigmine had a higher mortality and spleen bacterial burden when compared to infected mice exposed to saline solution only. The activated cholinergic anti-inflammatory pathway suppressed pathways necessary for tularemia resolution. Administration of AChE inhibitors to the individuals suffering from tularemia is contra-indicatory. Drugs based on AChE inhibition should be restricted when tularemia or disease with a similar pathogenesis is suspected.