Bio-accumulation of organic contaminants in Indo-Pacific humpback dolphins: Preliminary unique features of the brain and testes
Bio-accumulation of organic contaminants in Indo-Pacific humpback dolphins: Preliminary unique features of the brain and testes
复制标题
印度太平洋座头海豚有机污染物的生物累积：大脑和睾丸的初步独特特征
DOI：
10.1016/j.envpol.2020.115511
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发表时间：
2020
影响因子：
8.9
通讯作者：
Yuping Wu
中科院分区：
文献类型：
--
作者：
Xian Sun;Fengping Zhan;Ri-Qing Yu;Laiguo Chen;Yuping Wu
关于鲸目动物体内有机污染物的残留水平和同系物组成的信息很少。本研究调查了珠江口中华白海豚（Sousa chinensis）的鲸脂、血液、脑和睾丸中多氯联苯（PCBs）、多环芳烃（PAHs）和有机氯农药（OCPs）的含量。最低的鲸脂/组织分配系数的总和六氯环己烷（六六六）和六六六多环芳烃，而最高的是在六六六多氯联苯和总和二氯二苯基三氯乙烷（滴滴涕），可能归因于辛醇-水分配功能。脑和睾丸中OC的低水平理论上是由于血脑屏障、血睾丸屏障、污染物分子尺寸和脑和睾丸中独特的脂质组成。与其他污染物相比，发现灭蚁灵、七氯、狄氏剂和异狄氏剂的脑/血液和睾丸/血液平均分配系数较高，这将增加与安全相关的毒性和这些组织内污染物的生物利用度相关的风险。观察还表明，随着脂肪从鲸脂中移动，污染物可能会重新分布，导致组织（如大脑）浓度升高。因此，鲸脂较少的海豚可能更容易受到健康风险的影响。生活在PRE的印度太平洋座头鲸面临着巨大的风险，因为各种OC与非目标生物间接接触，影响动物的健康（毒性效应和积累）。我们的研究结果有助于了解OCs暴露对海洋哺乳动物发育神经毒性和生殖损害的潜在影响。
There is little information about the residue levels and congener composition of organic contaminants (OCs) in cetaceans. In the present study, we investigated the polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs) in the blubber, blood, brain and testes of Indo-Pacific humpback dolphins (Sousa chinensis) stranded in the Pearl River Estuary (PRE), China. The lowest blubber/tissue partition coefficients were found for sum hexachlorocyclohexanes (ΣHCHs) and ΣPAHs, while the highest were in ΣPCBs and sum dichlorodiphenyltrichloroethanes (ΣDDTs), likely attributing to the octanol-water partition features. The low levels of OCs in brain and testes theoretically resulted from the blood-brain barrier, blood-testes barrier, contaminant molecule dimensions and unique lipid compositions in the brain and testes. Compared with other contaminants, the higher mean brain/blood and testes/blood partition coefficients found for mirex, heptachlor, dieldrin and endrin would increase the risks associated with exposure-related toxicity and the bioavailability of contaminants within these tissues. Observations also suggest that as lipid mobilizes from blubber, contaminants may redistribute, leading to elevated tissue (such as brain) concentrations. Therefore, dolphins with less blubber may be more susceptible to health risks. The Indo-Pacific humpback dolphins living in PRE are at great risk due to variety of OCs in indirect contact with non-target organisms, affecting the health of animals (toxic effects and accumulation). Our findings contribute to the knowledge of the potential effects of OCs exposure on developmental neurotoxicity and reproductive damage in marine mammals.