The glomerular mesangium.
The glomerular mesangium.
复制标题
肾小球系膜。
DOI：
10.1016/s0272-6386(88)80032-5
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Kim,Y
中科院分区：
文献类型：
--
作者：
Michael,AF;Kim,Y
系膜不仅仅是肾小球毛细血管循环的支持结构。肾小球系膜细胞对各种血管活性介质作出反应，可能有助于调节系膜细胞的收缩性，从而调节肾小球灌注。周围的细胞外基质含有几种糖蛋白和胶原蛋白，它们可能影响抗原和抗体的免疫相互作用，并可能影响免疫复合物的分布。这些特性可能调节伊加肾病患者系膜中含有IgA的免疫复合物沉积的后果以及随后的临床疾病表达。
The mesangium is more than simply a support structure for glomerular capillary circulation. Mesangial cells respond to various vasoactive mediators and probably contribute to the regulation of mesangial cell contractility and, consequently, glomerular perfusion. The surrounding extracellular matrix contains several glycoproteins and collagens that may affect the immune interactions of antigens and antibodies and may possibly influence the disposition of immune complexes. These properties may modulate the consequences of deposition of IgA-containing immune complexes in the mesangium in patients with IgA nephropathy and the consequent expression of clinical disease.