Gold nanobipyramid-loaded black phosphorus nanosheets for plasmon-enhanced photodynamic and photothermal therapy of deep-seated orthotopic lung tumors
Gold nanobipyramid-loaded black phosphorus nanosheets for plasmon-enhanced photodynamic and photothermal therapy of deep-seated orthotopic lung tumors
复制标题
负载金纳米双锥体的黑磷纳米片用于等离激元增强光动力和光热疗法治疗深部原位肺肿瘤
DOI：
10.1016/j.actbio.2020.03.001
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发表时间：
2020
影响因子：
9.7
通讯作者：
Liu Jun
中科院分区：
文献类型：
--
作者：
Wang Jing;Zhang Han;Xiao Xiao;Liang Dong;Liang Xinyue;Mi Lan;Wang Jianfang;Liu Jun
人们已经探索了各种类型的光动力剂用于光动力疗法（PDT），以摧毁位于深层组织的癌症。然而，由于生物组织光学透明窗口的吸收较弱，这些试剂通常受到单线态氧 (1O2) 产率低的限制。因此，在这项工作中，我们通过在黑磷纳米片（BPNS）上组装金纳米双锥体（GNBP）开发了一种纳米复合材料。这种纳米复合材料可以在癌症治疗中通过局部表面等离子共振同时增强 1O2 的产生和热疗。作为二维无机光敏剂，BPNS与GNBP杂化形成BPNS-GNBP杂化纳米片。杂交通过等离子体增强光吸收显着增加了 BPNS 的 1O2 产量。该纳米复合材料表现出比单独的BPNS更高的光热转换效率。体外和体内试验表明，BPNS-GNBP杂化纳米复合材料由于同时进行双模态光疗而表现出良好的肿瘤抑制功效。在体内，该纳米复合材料抑制了深部肿瘤的生长，对患有原位A549人肺肿瘤的小鼠产生了最小的不良影响。综上所述，这些结果表明，我们的 BPNS-GNBP 纳米复合材料可以作为一种有前途的双模光治疗剂，在未来的癌症治疗中增强癌症治疗。意义声明在这项研究中，我们通过在黑磷纳米片（BPNS）上组装金纳米双锥体（GNBP）建立了一种新的纳米复合材料。这种纳米复合材料的表征表明，BPNS-GNBP 增强了 1O2 的生成和高温。 BPNS-GNBP由于同时具有双模式光疗功能，在体内和体外均表现出良好的肿瘤抑制功效。此外，BPNS-GNBP 抑制了体内深部肿瘤的生长，并且在携带原位 A549 人肺肿瘤的小鼠中没有显示出副作用。总的来说，这些结果表明 BPNS-GNBP 可以作为一种有前景的双模光治疗剂，在未来的临床应用中增强癌症治疗。
Various types of photodynamic agents have been explored for photodynamic therapy (PDT) to destroy cancers located in deep tissues. However, these agents are generally limited by low singlet oxygen (1O2) yields owing to weak absorption in the optical transparent window of biological tissues. Accordingly, in this work, we developed a nanocomposite through the assembly of gold nanobipyramids (GNBPs) on black phosphorus nanosheets (BPNSs). This nanocomposite could simultaneously enhance1O2generation and hyperthermia by localized surface plasmon resonance in cancer therapy. As two-dimensional inorganic photosensitizers, BPNSs were hybridized with GNBPs to form BPNS-GNBP hybrid nanosheets. The hybridization markedly increased1O2production by the BPNSs through plasmon-enhanced light absorption. The nanocomposite exhibited a higher photothermal conversion efficiency than the BPNSs alone.In vitroandin vivoassays indicated that the BPNS-GNBP hybrid nanocomposite exhibited good tumor inhibition efficacy owing to simultaneous dual-modality phototherapy.In vivo, the nanocomposite suppressed deep-seated tumor growth with minimal adverse effects in mice bearing orthotopic A549 human lung tumors. Taken together, these results demonstrated that our BPNS-GNBP nanocomposite could function as a promising dual-modality phototherapeutic agent for enhanced cancer therapy in future cancer treatments.Statement of SignificanceIn this study, we established a new nanocomposite by assembly of gold nanobipyramids (GNBPs) on black phosphorus nanosheets (BPNSs). Characterization of this nanocomposite showed that BPNS-GNBP enhanced1O2generation and hyperthermia. BPNS-GNBP exhibited good tumor inhibition efficacyin vivoandin vitroowing to simultaneous dual-modal phototherapy functions. Moreover, BPNS-GNBP suppressed deep-seated tumor growthin vivoand did not show adverse effects in mice bearing orthotopic A549 human lung tumors. Overall, these results showed that BPNS-GNBP may be used as a promising dual-modal phototherapeutic agent for enhanced cancer therapy in future clinical applications.