Randomized trial of cognitive speed of processing training in Parkinson disease
Randomized trial of cognitive speed of processing training in Parkinson disease
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DOI：
10.1212/wnl.0b013e3182a823ba
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发表时间：
2013-10-08
期刊：
影响因子：
9.9
通讯作者：
Uc, Ergun Y.
中科院分区：
文献类型：
--
作者：
Edwards, Jerri D.;Hauser, Robert A.;Uc, Ergun Y.
目的：探讨认知加工速度训练（SOPT）对帕金森病（PD）患者的疗效。方法：将87名40岁或以上、诊断为Hoehn & Yahr 1-3期特发性PD并接受稳定药物治疗的成年人随机分配至20小时自我给药SOPT（使用InSight软件）或无接触对照条件。参与者在基线和3个月的培训后（或同等延迟）进行评估。主要结果指标是有用视野测试（UFOV）的表现，次要结果包括认知自我感知和抑郁症状。结果表明，与对照组相比，随机分配至SOPT组的受试者在UFOV性能方面的改善显著更大，Wilks lambda = 0.938，F（1，72）= 4.79，p = 0.032，偏eta（2）= 0.062。结果表明，训练对次要结果无显著影响，Wilks lambda = 0.987，F-2，F-70 < 1，p = 0.637，partial eta（2）= 0.013。结论：轻中度PD患者可以自我进行SOPT，并改善其认知处理速度，如UFOV（一个预测老年和PD驾驶性能的可靠指标）所示。进一步的研究应建立如果PD的人的经验纵向的好处，这种培训，如果改善转化为效益的功能活动，如driving.Classification的证据：这项研究提供了第三类证据，SOPT改善UFOV性能的人在轻度至中度阶段的PD。
Objective: To examine the efficacy of cognitive speed of processing training (SOPT) among individuals with Parkinson disease (PD). Moderators of SOPT were also examined.Methods: Eighty-seven adults, 40 years of age or older, with a diagnosis of idiopathic PD in Hoehn & Yahr stages 1-3 and on a stable medication regimen were randomized to either 20 hours of self-administered SOPT (using InSight software) or a no-contact control condition. Participants were assessed at baseline and after 3 months of training (or an equivalent delay). The primary outcome measure was useful field of view test (UFOV) performance, and secondary outcomes included cognitive self-perceptions and depressive symptoms.Results: Results indicated that participants randomized to SOPT experienced significantly greater improvements on UFOV performance relative to controls, Wilks lambda = 0.938, F (1,72) = 4.79, p = 0.032, partial eta(2) = 0.062. Findings indicated no significant effect of training on secondary outcomes, Wilks lambda = 0.987, F-2,F-70 < 1, p = 0.637, partial eta(2) = 0.013.Conclusions: Patients with mild to moderate stage PD can self-administer SOPT and improve their cognitive speed of processing, as indexed by UFOV (a robust predictor of driving performance in aging and PD). Further research should establish if persons with PD experience longitudinal benefits of such training and if improvements translate to benefits in functional activities such as driving.Classification of evidence: This study provides Class III evidence that SOPT improves UFOV performance among persons in the mild to moderate stages of PD.