Epinephrine accumulation in rat brain after chronic administration of pargyline and LY 51641--comparison with other brain amines.
Epinephrine accumulation in rat brain after chronic administration of pargyline and LY 51641--comparison with other brain amines.
复制标题
长期服用帕吉林和 LY 51641 后大鼠脑中肾上腺素的积累——与其他脑胺的比较。
DOI：
10.1016/0006-8993(85)90101-5
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发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
Barchas,JD
中科院分区：
文献类型：
--
作者：
Mefford,IN;Roth,KA;Jurik,SM;Collman,V;McIntire,S;Tolbert,L;Barchas,JD
在给予单胺氧化酶（MAO）抑制剂21天后，测量了大鼠大脑区域的生物胺和代谢物浓度。慢性给予选择性MAO a型抑制剂LY 51641后，肾上腺素浓度从350 %增加到500%。去甲肾上腺素、多巴胺和血清素的相对积累要少得多。肾上腺素的显著相对积累可能与MAO A型抑制剂治疗抑郁症的疗效有关。
Concentrations of biogenic amines and metabolites were measured in regions of rat brain following administration of monoamine oxidase (MAO) inhibitors for 21 days. Epinephrine concentrations were increased from 350 to 500% following chronic administration of LY 51641, a selective inhibitor of MAO type A. Norepinephrine, dopamine and serotonin showed much lesser relative accumulation. The marked relative accumulation of epinephrine may be related to the efficacy of inhibitors of MAO type A in the treatment of depression.