A TRANSPLANTABLE RABBIT CARCINOMA ORIGINATING IN A VIRUS-INDUCED PAPILLOMA AND CONTAINING THE VIRUS IN MASKED OR ALTERED FORM.
A TRANSPLANTABLE RABBIT CARCINOMA ORIGINATING IN A VIRUS-INDUCED PAPILLOMA AND CONTAINING THE VIRUS IN MASKED OR ALTERED FORM.
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DOI：
10.1084/jem.71.6.813
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发表时间：
1940-05-31
期刊：
影响因子：
--
通讯作者：
Rous P
中科院分区：
文献类型：
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作者：
Kidd JG;Rous P
由病毒诱导的兔乳头状瘤衍生的鳞状细胞癌已在14个连续的动物群体中繁殖。现在，它在大多数被移植的个体中迅速生长，早期死亡，经常转移。最初的癌症是表皮细胞的改变的结果，表皮细胞已经被病毒变成了肿瘤，而后者，或与之密切相关的一种物质，在恶性组织中持续存在并增加，正如对前十组癌变动物的血液的研究所显示的那样。一种能够在体外特异性中和病毒的抗体出现在肿瘤逐渐扩大的每个新宿主的血液中，其滴度与长期携带大乳头状瘤的动物的滴度相当。这种抗体在正常的兔子和那些癌细胞没有生长的兔子身上都不存在。考虑了这些事实的含义。
A squamous cell carcinoma derived from a virus-induced rabbit papilloma has been propagated in fourteen successive groups of animals. It grows rapidly now in most individuals to which it is transplanted, killing early and metastasizing frequently. The original cancer was the outcome of alterations in epidermal cells already rendered neoplastic by the virus, and the latter, or an agent nearly related to it, has persisted and increased in the malignant tissue, as a study of the blood of the first ten groups of cancerous animals has shown. An antibody capable of specifically neutralizing the virus in vitro appeared in the blood of every new host in which the tumor enlarged progressively, and reached a titer comparable with that obtaining in animals which had long carried large papillomas. The antibody was absent from normal rabbits and those in which the cancer failed to grow. The implications of these facts are considered.