Birth weight and metabolic syndrome in adults: meta-analysis
Birth weight and metabolic syndrome in adults: meta-analysis
复制标题
DOI：
10.1590/s0034-89102008000100002
复制
发表时间：
2008-02-01
期刊：
影响因子：
--
通讯作者：
Horta, Bernardo Lessa
中科院分区：
文献类型：
--
作者：
Silveira, Vera Maria Freitas da;Horta, Bernardo Lessa
目的：评估出生体重对成人代谢综合征的影响的已发表证据。方法：检索PubMed和LILACS数据库中从1966年到2006年5月发表的文章。使用的术语是：“出生体重”、“出生体重”、“子宫内生长受限（IUGR）"、“胎儿生长迟缓”、“代谢综合征”、“X综合征”、“Reaven's X综合征”。有224项研究报告了出生体重与代谢综合征或其组分之间的相关性，这些研究被认为是合格的。11项研究提供了优势比，并纳入了荟萃分析。结果：除两项研究外，所有研究均报告了出生体重与代谢综合征之间的负相关关系。低出生体重与正常出生体重受试者之间的比较显示，代谢综合征的随机效应比值比为2.53（95% CI：1.57;4.08）。漏斗图显示了发表偏倚，但即使在超过400例受试者的研究中，结果仍然显著（合并优势比：2.37（95%CI：1.15;4.90）。
OBJECTIVES: To assess published evidences of the effect of birth weight on metabolic syndrome in adults.METHODS: PubMed and LILACS databases were searched for articles published from 1966 through May 2006. The terms used were: "birth weight", "birthweight", "intra-uterine growth restriction (IUGR)", "fetal growth retardation", "metabolic syndrome", "syndrome X", "Reaven's X syndrome". Two hundred and twenty-four studies reporting estimates of the association between birth weight and metabolic syndrome or its components were considered eligible. Eleven studies provided odds ratios and were included in the meta-analysis.RESULTS: All but two studies reported an inverse relationship between birth weight and metabolic syndrome. A comparison between low birth weight vs. normal birth weight subjects showed the random effects odds ratio for metabolic syndrome was 2.53 (95% CI: 1.57;4.08). The funnel plot graphic suggests a publication bias but, even in the studies with more than 400 subjects, the results remained significant (pooled odds ratio: 2.37 (95% CI: 1.15;4.90).CONCLUSIONS: Low birth weight increases the risk of metabolic syndrome in adults.