The inflammatory reflex and the role of complementary and alternative medical therapies.
The inflammatory reflex and the role of complementary and alternative medical therapies.
复制标题
炎症反射以及互补和替代医疗疗法的作用。
DOI：
10.1196/annals.1393.013
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发表时间：
2009-08
影响因子：
5.2
通讯作者：
Tracey KJ
中科院分区：
文献类型：
--
作者：
Oke SL;Tracey KJ
身体抵御病原体入侵或组织损伤的第一道防御系统是先天免疫系统。由于过度的免疫反应可能具有破坏性，因此抗炎机制可以控制促炎反应并防止损伤。胆碱能抗炎途径是抑制先天炎症反应的神经机制。有关免疫系统神经支配的知识为探索以前未被认识的疾病治疗技术提供了独特的机会。它还可以考虑补充和替代医学疗法（例如冥想和针灸）的神经学基础。这一不断发展的研究领域对慢性炎症性疾病的发病机制具有重要意义，包括炎症性肠病、类风湿性关节炎、2 型糖尿病和其他细胞因子过度释放的疾病。
The body’s first defense against invading pathogens or tissue injury is the innate immune system. Since excessive immune responses can be damaging, anti-inflammatory mechanisms function to control the pro-inflammatory response and prevent injury. The cholinergic anti-inflammatory pathway is a neural mechanism that suppresses the innate inflammatory response. Knowledge concerning innervation of the immune system offers a unique opportunity to explore previously unrecognized techniques to treat disease. It also enables consideration of the neurological basis of complementary and alternative medical therapies, such as meditation and acupuncture. This evolving area of research has implications for the pathogenesis of chronic inflammatory conditions including inflammatory bowel disease, rheumatoid arthritis, type 2 diabetes, and other conditions of excessive cytokine release.