Relationship between subjective and actigraphy-measured sleep in 237 patients with metastatic colorectal cancer.
Relationship between subjective and actigraphy-measured sleep in 237 patients with metastatic colorectal cancer.
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DOI：
10.1007/s11136-017-1617-2
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Innominato PF
中科院分区：
文献类型：
--
作者：
Palesh O;Haitz K;Lévi F;Bjarnason GA;Deguzman C;Alizeh I;Ulusakarya A;Packer MM;Innominato PF
癌症患者经常经历睡眠和昼夜节律功能障碍。到目前为止，只有少数研究同时使用问卷调查和体动记录来评估癌症患者的睡眠和昼夜节律功能。我们试图评估转移性结肠癌（MCC）患者的客观睡眠和昼夜节律参数及其与症状和生活质量（QOL）的关系。患者在EORTC QLQ-C30中报告了主观睡眠问题。睡眠和昼夜节律参数是使用患者佩戴72小时的腕关节活动记录仪计算的。237例MCC患者（年龄：60.4岁;范围：20.7-77.6;男性/女性比例：1.66）参加了这项横断面研究。63.4%的患者（S+）报告了主观睡眠问题。在S+和S-患者之间未观察到任何睡眠参数（睡眠效率、睡眠潜伏期、总睡眠时间、总卧床时间、入睡后觉醒、活动深相）的差异。然而，S+患者的昼夜节律功能明显差于S-患者（96.4% vs 98.1%; p= 0.005）。主观睡眠不良和客观昼夜节律功能障碍的存在对症状和QOL领域产生负面影响（p= 0.038）。主观报告的睡眠问题与MCC患者客观测量的睡眠参数较差无关，尽管其与昼夜休息-活动节律紊乱和生活质量较差相关。这些发现与先前对癌症患者的研究一致，因为在某些睡眠领域的主观和客观睡眠测量之间存在不一致的关系。这项研究支持了癌症患者自我报告的睡眠和昼夜节律功能的客观测量的耦合评估的价值。
Patients with cancers frequently experience sleep and circadian dysfunction. To date, only a few studies have used both a questionnaire and actigraphy for concomitant evaluation of sleep and circadian function in patients with cancer. We sought to evaluate objective sleep and circadian parameters in metastatic colon cancer (MCC) patients and their associations with symptoms and quality of life (QOL). Patients reported subjective sleep problems on the EORTC QLQ-C30. Sleep and circadian parameters were calculated using a wrist-actigraph that patients wore for 72 hours. 237 Patients with MCC (age: 60.4 years; range: 20.7–77.6; Male/Female ratio: 1.66) participated in this cross-sectional study. Subjective sleep problems were reported by 63.4% of patients (S+). No differences in any sleep parameters (sleep efficiency, sleep latency, total sleep time, total time in bed, wake after sleep onset, activity bathyphase) were observed between S+ and S- patients. However, S+ patients displayed a significantly worse circadian function than S-patients (96.4% versus 98.1%; p=.005). Presence of poor subjective sleep and objective circadian dysfunction negatively affected symptoms and QOL domains (p=.038). Subjective report of sleep problems was not associated with worse objectively-measured sleep parameters in patients with MCC although it was associated with disrupted circadian rest-activity rhythm and poorer QOL. These findings coincide with prior research in cancer patients in that an inconsistent relationship exists between subjective and objective sleep measurements on some sleep domains. This study supports the value of coupled evaluation of self-reported and objective measures of sleep and circadian function in cancer patients.
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