The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
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DOI：
10.1038/nm.2471
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发表时间：
2011-10-01
期刊：
影响因子：
82.9
通讯作者：
Tu, Youyou
中科院分区：
文献类型：
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作者：
Tu, Youyou
在我们工作的第一阶段，我们调查了2000多种中草药制剂，并确定了640种可能具有抗疟疾活性的药物。从200多种中草药中提取的380多种提取物对小鼠疟疾模型进行了评价。然而，进展并不顺利，没有轻易取得重大成果。转折点出现在黄花蒿提取物显示出对寄生虫生长有一定程度的抑制。然而，这一观察结果在随后的实验中无法重现，似乎与文献中记录的内容相矛盾。为了寻求解释，我们对文献进行了深入的回顾。使用青蒿（青蒿的中文名）缓解疟疾症状的唯一文献出现在葛红的A
During the first stage of our work, we investigated more than 2,000 Chinese herb preparations and identified 640 hits that had possible antimalarial activities. More than 380 extracts obtained from~ 200 Chinese herbs were evaluated against a mouse model of malaria. However, progress was not smooth, and no significant results emerged easily. The turning point came when an Artemisia annua L. extract showed a promising degree of inhibition against parasite growth. However, this observation was not reproducible in subsequent experiments and appeared to be contradictory to what was recorded in the literature. Seeking an explanation, we carried out an intensive review of the literature. The only reference relevant to use of qinghao (the Chinese name of Artemisia annua L.) for alleviating malaria symptoms appeared in Ge Hong’s A