Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years
Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years
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DOI：
10.1016/s0140-6736(98)10321-5
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发表时间：
1999-08-14
期刊：
影响因子：
168.9
通讯作者：
Martinez, FD
中科院分区：
文献类型：
--
作者：
Stein, R;Sherrill, D;Martinez, FD
研究背景：呼吸道合胞病毒（RSV）引起的早期下呼吸道疾病与随后儿童期发生的喘鸣性酸过敏症之间的关系尚不清楚。我们研究了这种关系的儿童谁发生下呼吸道疾病，3岁之前。方法儿童在出生时登记，下呼吸道疾病的情况下，由医生确定。对患病时采集的标本进行病毒检测。根据下呼吸道疾病的类型和原因，将儿童分为五组。随后对儿童进行前瞻性随访，直至13岁，我们测量了喘息频率、肺功能和特应性状态（过敏皮肤点刺试验、血清IgE浓度）。
Background The relation between lower respiratory tract illnesses in early life caused by the respiratory syncytial virus (RSV) and the subsequent development of wheezing acid atopy in childhood is not well understood. We studied this relation in children who had lower respiratory tract illnesses that occurred before 3 years of age.Methods Children were enrolled at birth and cases of lower respiratory tract illness were ascertained by a physician. Viral tests were done for specimens collected at the time of the illness. Children were classified into five groups according to type and cause of lower respiratory tract illness. Children were then followed prospectively up to age 13, and we measured frequency of wheezing, pulmonary function, and atopic status (allergy skin-prick tests, serum IgE concentrations).Findings RSV lower respiratory tract illnesses were associated with an increased risk of infrequent wheeze (odds ratio 3.2 [95% CI 2.0-5.0], p