A landmark-free framework for the detection and description of shape differences in embryos.
A landmark-free framework for the detection and description of shape differences in embryos.
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用于检测和描述胚胎形状差异的无地标框架。
DOI：
10.1109/iembs.2011.6091276
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Cox,LL
中科院分区：
文献类型：
--
作者：
Rolfe,SM;Shapiro,LG;Cox,TC;Maga,AM;Cox,LL
本文介绍了一种新的方法来量化和表征的形状变化，在早期面部发育过程中，不使用标志。标志物传统上用于形态学分析，但很少能在胚胎发育的所有阶段可靠地识别。该方法使用可变形配准来产生描述两幅图像之间的点对应的稠密向量场。从可变形向量场中提取低级和中级特征，以找到生物相关的有组织差异区域。这些方法被证明是检测区域的差异时，评估鸡胚图像扭曲的小幅度变形的关键区域面中部的发展。
This paper introduces a new method to quantify and characterize shape changes during early facial development without the use of landmarks. Landmarks are traditionally used in morphometric analysis, but very few can be identified reliably across all stages of embryonic development. This method uses deformable registration to produce a dense vector field describing the point correspondences between two images. Low and mid-level features are extracted from the deformable vector field to find regions of organized differences that are biologically relevant. These methods are shown to detect regions of difference when evaluated on chick embryo images warped with small magnitude deformations in regions critical to midfacial development.