Insights into ABC transport in archaea
Insights into ABC transport in archaea
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DOI：
10.1023/b:jobb.0000019593.84933.e6
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发表时间：
2004-02-01
影响因子：
3
通讯作者：
Driessen, AJM
中科院分区：
文献类型：
--
作者：
Albers, SV;Koning, SM;Driessen, AJM
在古细菌中，atp结合盒（ABC）转运体在底物摄取、输出和渗透调节中起着至关重要的作用。古细菌底物结合蛋白依赖的ABC转运体对其同源底物具有非常高的亲和力，这使这些生物能够有效地从其环境中清除底物，即使只有低浓度的底物。对古细菌生活方式的进一步适应尤其见于结构域组织和底物结合蛋白在膜上的锚定。对14个古细菌基因组结合蛋白信号肽的检测显示，euryarchaeotes和crenarchaeotes之间存在明显差异。此外，对三种测序的热球菌菌株的ABC转运蛋白进行了分析和比较。
In archaea, ATP-binding cassette (ABC) transporters play a crucial role in substrate uptake, export, and osmoregulation. Archaeal substrate-binding-protein-dependent ABC transporters are equipped with a very high affinity for their cognate substrates which provide these organisms with the ability to efficiently scavenge substrates from their environment even when present only at low concentration. Further adaptations to the archaeal way of life are especially found in the domain organization and anchoring of the substrate-binding proteins to the membrane. Examination of the signal peptides of binding proteins of 14 archaeal genomes showed clear differences between euryarchaeotes and crenarchaeotes. Furthermore, a profiling and comparison of ABC transporters in the three sequenced pyrococcal strains was performed.