Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
复制标题
鞍区低度恶性软骨肉瘤：病例报告及文献复习
DOI：
10.2147/ott.s221898
复制
发表时间：
2019
影响因子：
4
通讯作者：
Y. Qi
中科院分区：
文献类型：
--
作者：
Zhen Zhang;L. Pang;Ning Wang;Zhong Li;Yunjuan Cao;Wen;W. Liang;Jin;H. Zou;Y. Qi
摘要低度恶性软骨肉瘤是一种非常罕见的颅内肿瘤，尤其是发生在鞍区。在此，我们描述一个不寻常的情况下，LGC发生在鞍区。一名52岁男子出现视力下降超过3个月，但没有出现之前病例中报告的头痛症状。MRI显示肿瘤最大直径为7 cm，位于鞍区左侧。我们描述了特定的病理特征。组织学上，肿瘤有息肉样区域，低倍镜下呈分叶状生长。高倍镜下，肿瘤由软骨基质中的小细胞和深染核组成，交替出现疏松的低细胞区和丰富的粘液区。在我们的案例中，LGC需要与choreostomy区分开来。免疫组化：瘤细胞呈弥漫性S-100和波形蛋白阳性，IDH 1呈胞浆弱阳性。Ki-67标记指数小于5%。此外，AE 1/3、EMA和CK 19均为阴性，可用于排除脉络膜炎。本病例报告扩展了LGC的文献，将有助于临床医生和病理学家更好地了解这个实体。
Abstract Low-grade chondrosarcoma (LGC) is a very rare intracranial tumor, particularly in the sellar area. Herein, we describe an unusual case of LGC occurring in the sellar area. A 52-year-old man presented with diminution of vision for more than 3 months, but did not exhibit headaches reported in previous cases. MRI showed that the maximum size of the tumor was 7 cm on the left side of the saddle. We characterized the specific pathological characteristics. Histologically, the tumor had polypoid areas and a lobulated growth pattern under low-power examination. At high magnification, the tumor consisted of small cells with hyperchromatic nuclei in the cartilage matrix, with an alternating loose hypocellular zone and rich myxoid area. In our case, LGC needed to be distinguished from chordoma. Immunohistochemically, the tumor cells showed diffuse positivity for S-100 and vimentin, IDH1 was weakly cytoplasm positive. The Ki-67 labeling index was less than 5%. Additionally, AE1/3, EMA, and CK19 were negative, which could be used to exclude chordoma. This case report expands the literature on LGC and will help clinicians and pathologists better understand this entity.