Hippocampal SH2-containing protein-tyrosine phosphatases are involved in extinction of contextual fear
Hippocampal SH2-containing protein-tyrosine phosphatases are involved in extinction of contextual fear
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DOI：
10.1097/wnr.0b013e328338ba4f
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发表时间：
2010-06
期刊：
影响因子：
1.7
通讯作者：
Tomoko Isosaka;S. Yuasa
中科院分区：
文献类型：
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作者：
Tomoko Isosaka;S. Yuasa
情境恐惧记忆是通过将动物单独暴露在情境中而不与无条件刺激相结合而减弱的，这种现象被称为恐惧消退。在这项研究中，我们证明了立体定向注射含有Src同源2蛋白酪氨酸磷酸酶1和2 （SHP1/2）的抑制剂NSC87877到海马中可以显著抑制小鼠情境恐惧的消退。然而，海马内注射NSC87877对情境恐惧条件反射的初始记忆形成没有影响。这些发现表明，海马体中SHP1/2的活动参与了情境恐惧消退的控制。
Contextual fear memory is attenuated by re-exposure of animals to a context alone without pairing it with an unconditioned stimulus, and this phenomenon is referred to as fear extinction. In this study we demonstrated that stereotaxic injection of an inhibitor of Src homology 2-containing protein-tyrosine phosphatases 1 and 2 (SHP1/2), NSC87877, into the hippocampus significantly suppressed extinction of contextual fear in the mouse. Intra-hippocampal injection of NSC87877, however, had no effect on the initial memory formation in contextual fear conditioning. These findings suggest that SHP1/2 activity in the hippocampus is involved in the control of contextual fear extinction.