Plasmonic Janus hybrids for the detection of small metabolites.
Plasmonic Janus hybrids for the detection of small metabolites.
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DOI：
10.1039/c8tb01587b
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发表时间：
2018-11
期刊：
影响因子：
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通讯作者：
Haiyang Su;Tingting Liu;Lin Huang;Jingyi Huang;Jing Cao;Hengquan Yang;Jian Ye;Jian Liu
中科院分区：
文献类型：
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作者：
Haiyang Su;Tingting Liu;Lin Huang;Jingyi Huang;Jing Cao;Hengquan Yang;Jian Ye;Jian Liu
先进的生物分析平台依赖于具有定制结构参数的材料。在此，我们组装等离子体Janus混合物用于小代谢物的激光解吸/电离质谱（LDIMS）检测。我们采用Janus颗粒（周期性介孔有机硅（PMO）结合碳球）作为核心材料和负载银纳米粒子作为纳米壳。Janus核心颗粒增强了由于各向异性性质的疏水性和亲水性分子的LDI MS检测。此外，由于选择性LDI过程，等离子体纳米壳使得能够在生物混合物中利用银加合直接检测代谢物。此外，我们证明了Janus杂交体的可调表面化学，用于在低浓度（4 pM）下富集和鉴定代谢物。我们的工作为代谢分析工具的开发和生物分析平台材料的设计做出了贡献。
Advanced bio-analytical platforms rely on materials with tailored structural parameters. Herein, we assembled plasmonic Janus hybrids for laser desorption/ionization mass spectrometry (LDI MS) detection of small metabolites. We applied Janus particles (periodic mesoporous organosilica (PMO) in conjunction with carbon spheres) as core materials and loaded silver nanoparticles as nanoshells. Janus core particles enhanced the LDI MS detection of both hyhrophobic and hydrophilic molecules due to anisotropic properties. Moreover, plasmonic nanoshells enabled direct metabolite detection with silver adduction in bio-mixtures, due to the selective LDI process. Furthermore, we demonstrated the tunable surface chemistry of Janus hybrids for the enrichment and identification of metabolites at low concentration (4 pM). Our work contributed to the development of tools for metabolic analysis and design of materials for bio-analytical platforms.