Clathrin heavy chain is involved in infection of Candidatus Liberibacter asiaticus in the host vector Diaphorina citri.
Clathrin heavy chain is involved in infection of Candidatus Liberibacter asiaticus in the host vector Diaphorina citri.
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DOI：
10.1111/1744-7917.13305
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发表时间：
2023-12
期刊：
影响因子：
4
通讯作者：
Lianjie Xie;Xiangdong Zeng;Muhammad Bilal Amir;Xiaojin Zou;Jingfu Yuan;Haizhong Yu;Zhanjun Lu;Wei Chen
中科院分区：
文献类型：
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作者：
Lianjie Xie;Xiangdong Zeng;Muhammad Bilal Amir;Xiaojin Zou;Jingfu Yuan;Haizhong Yu;Zhanjun Lu;Wei Chen
柑橘黄龙病（HLB）已成为一个全球性问题，在140个以柑橘生产闻名的国家中，有51个国家确诊病例（Wang，2019）。据信引起HLB的主要病原体是未培养的革兰氏阴性细菌亚洲黄龙杆菌（CLas）。受感染的柑橘树在其叶片上表现出不规则的斑点变黄，导致果实产量降低和质量受损。不幸的是，目前还没有有效的治疗CLas的方法，CLas通常被称为"柑橘产业的癌症"（Wang et al.，2017年）。除了运输苗木外，亚洲柑橘木虱（Diaphorina citri）作为HLB传播的主要媒介也起着至关重要的作用。感染D.携带CLas病原体的柑橘可以将其从患病树木传播到健康树木，这对了解HLB的传播机制和制定有效的控制策略构成了重大挑战（Huang等人，2021年）。感染D. citri、CLas具有胞外分泌特性。最初，CLas穿过D.在这些细胞内进行大量增殖，在基底膜附近形成聚集体。随后，它穿过中肠上皮细胞层和基底膜，进入血淋巴（Ghanim等人，2016年、2017年）。CLas在D.柑橘，循环系统和繁殖，同时跨越多个组织和器官，在-
Dear Editor, Citrus huanglongbing (HLB) has emerged as a global issue, with confirmed cases in 51 out of 140 countries known for citrus production (Wang, 2019). The primary pathogen believed to cause HLB is Candidatus Liberibacter asiaticus (CLas), an uncultured gram-negative bacterium. Infected citrus trees exhibit irregular blotchy yellowing on their leaves, resulting in reduced fruit yield and compromised quality. Unfortunately, there is currently no effective cure for CLas, which is commonly referred to as the “cancer of the citrus industry”(Wang et al., 2017). In addition to the transportation of nursery stock, the Asian citrus psyllid (Diaphorina citri) plays a crucial role as the primary vector in the spread of HLB. Infected D. citri harboring the CLas pathogen can transmit it from diseased to healthy trees, posing significant challenges in understanding the transmission mechanisms of HLB and developing effective control strategies (Huang et al., 2021). Upon infecting D. citri, CLas exhibits traits of extracellular secretion. Initially, CLas traverses the midgut epithelial cells of D. citri, where it undergoes substantial proliferation within these cells, forming aggregations in proximity to the basement membrane. Subsequently, it crosses the midgut epithelial cell layer and basement membrane, entering the hemolymph (Ghanim et al., 2016, 2017). CLas establishes itself as an endosymbiont within D. citri, circulating systemically and reproducing while crossing multiple tissues and organs, in-