ENDOTHELIAL EXPRESSION OF A MONONUCLEAR LEUKOCYTE ADHESION MOLECULE DURING ATHEROGENESIS
ENDOTHELIAL EXPRESSION OF A MONONUCLEAR LEUKOCYTE ADHESION MOLECULE DURING ATHEROGENESIS
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DOI：
10.1126/science.1990440
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发表时间：
1991-02-15
期刊：
影响因子：
56.9
通讯作者：
GIMBRONE, MA
中科院分区：
文献类型：
--
作者：
CYBULSKY, MI;GIMBRONE, MA
一种对单核白细胞有选择性的诱导型兔内皮细胞粘附分子已被鉴定。 这种粘附蛋白在活化的培养内皮细胞表面上以两种形式表达，118和98千道尔顿，每种形式的氨基末端序列与人VCAM-1高度同源。 在饮食性高胆固醇血症和Watanabe遗传性高胆固醇血症兔动脉粥样硬化模型中，发现这种粘附分子以局部方式由覆盖早期泡沫细胞病变的主动脉内皮表达。 这种病变局部表达提示动脉粥样硬化形成过程中单核白细胞募集的潜在内皮依赖性机制，并可能为早期动脉粥样硬化提供分子标志物。
An inducible rabbit endothelial adhesion molecule that is selective for mononuclear leukocytes has been identified. This adhesion protein was expressed on the surface of activated cultured endothelium in two forms, 118 and 98 kilodaltons, the amino-terminal sequence of each being highly homologous to human VCAM-1. In dietary hypercholesterolemic and Watanabe heritable hyperlipidemic rabbit models of atherosclerosis, this adhesion molecule was found to be expressed in a localized fashion by aortic endothelium that overlies early foam cell lesions. This lesion-localized expression suggests a potential endothelium-dependent mechanism for mononuclear leukocyte recruitment during atherogenesis and may provide a molecular marker for early atherosclerosis.