Measurement of vascular volume in experimental rat tumors by 19F magnetic resonance imaging.
Measurement of vascular volume in experimental rat tumors by 19F magnetic resonance imaging.
复制标题
通过 19F 磁共振成像测量实验大鼠肿瘤中的血管体积。
DOI：
10.1097/00004424-199308000-00012
复制
发表时间：
1993
影响因子：
6.7
通讯作者：
Lin,R
中科院分区：
文献类型：
--
作者：
Meyer,KL;Joseph,PM;Mukherji,B;Livolsi,VA;Lin,R
原理和方法：肿瘤血管体积的体内评估可以为治疗计划或治疗效果的评估提供有用的信息。我们的研究的目标是测量百分之血管体积在两个实验肿瘤亚系使用19 F磁共振成像（MRI）和评估肿瘤血容量的变化与growth.METHODS。全氟三丁胺（FTBA）的乳液作为血管造影剂19 F MRI。通过19F MRI测量肿瘤脉管系统中乳剂的量，并用于计算血管体积百分比。使用染料Hoechst 33342进行了血管容积的单独离体研究。共5只大鼠进行了研究，MRI和14离体方法。结果。在成像和Hoechst染料研究中测得的血管体积值的百分比的范围分别为2%至9%和1.25至7%，分别。随着肿瘤体积的增加，血管体积百分比下降的趋势是明显的，在一个肿瘤subline.CONCLUSIONS.定量19 F MRI技术是有效的测量血管体积百分比和血管体积的变化与增长。
RATIONALE AND OBJECTIVES.In-vivo assessment of tumor vascular volume may provide useful information for treatment planning or the assessment of treatment effectiveness. The goals of our study were to measure percent vascular volume in two experimental tumor sublines using 19 F magnetic resonance imaging (MRI) and to assess changes in tumor blood volume with growth.METHODS.An emulsion of perfluorotributylamine (FTBA) was used as a vascular contrast agent for 19 F MRI. The amount of emulsion in the tumor vasculature was measured by 19 F MRI and used to calculate percent vascular volume. A separate ex-vivo study of vascular volume was conducted using the dye Hoechst 33342. A total of five rats were studied by MRI and 14 by the ex-vivo method.RESULTS.The ranges of percent vascular volume values measured in the imaging and Hoechst dye studies were 2% to 9% and 1.25 to 7%, respectively. A trend toward decreasing percent vascular volume with increasing tumor volume was evident in one tumor subline.CONCLUSIONS.The quantitative 19 F MRI technique was effective for measuring percent vascular volume and changes in vascular volume with growth.