Human Y Chromosome Haplogroup N: A Non-trivial Time-Resolved Phylogeography that Cuts across Language Families
Human Y Chromosome Haplogroup N: A Non-trivial Time-Resolved Phylogeography that Cuts across Language Families
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DOI：
10.1016/j.ajhg.2016.05.025
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发表时间：
2016-07-07
影响因子：
9.8
通讯作者：
Rootsi, Siiri
中科院分区：
文献类型：
--
作者：
Ilumae, Anne-Mai;Reidla, Maere;Rootsi, Siiri
父本单倍群（hg） N分布于东南亚至东欧。在许多语言上和常染色体上不同的人群中，形成这种主要Y染色体谱系的人口统计过程在以前一直没有得到解决。基于94条高覆盖率重测序的Y染色体，我们建立并确定了详细的hg N系统发育。我们从56个群体的6521个样本中收集了1631个hg N Y染色体的16个区分二元标记来评估地理结构。N4亚枝在N2a1和N3亚枝之前出现，主要分布在北部，但后两个亚枝表现出更复杂的分支模式，表明了近期扩张的区域对比。特别是，许多具有共同N3a3’6祖先的突出和明确的分支出现在区域不同的欧亚北部人群中，表明在过去5000年里几乎同时存在区域多样化和扩张。这种父系遗传亲缘性与相关的较高程度的语言多样性是分离的。
The paternal haplogroup (hg) N is distributed from southeast Asia to eastern Europe. The demographic processes that have shaped the vast extent of this major Y chromosome lineage across numerous linguistically and autosomally divergent populations have previously been unresolved. On the basis of 94 high-coverage re-sequenced Y chromosomes, we establish and date a detailed hg N phylogeny. We evaluate geographic structure by using 16 distinguishing binary markers in 1,631 hg N Y chromosomes from a collection of 6,521 samples from 56 populations. The more southerly distributed sub-clade N4 emerged before N2a1 and N3, found mostly in the north, but the latter two display more elaborate branching patterns, indicative of regional contrasts in recent expansions. In particular, a number of prominent and well-defined clades with common N3a3 ' 6 ancestry occur in regionally dissimilar northern Eurasian populations, indicating almost simultaneous regional diversification and expansion within the last 5,000 years. This patrilineal genetic affinity is decoupled from the associated higher degree of language diversity.