Time resolved photon counting CMOS SPAD arrays for clinical imaging and spectroscopy
Time resolved photon counting CMOS SPAD arrays for clinical imaging and spectroscopy
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用于临床成像和光谱学的时间分辨光子计数 CMOS SPAD 阵列
DOI：
10.1117/12.2657883
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tanner M
中科院分区：
文献类型：
--
作者：
Tanner M
单光子探测通过观察皮秒到纳秒尺度上的时序动态提供了增强的测量。这在许多领域都得到了广泛的利用，包括生物或医疗技术。然而，由于单点检测器的采集限制以及组合使用大量检测器的实际和成本限制，临床的实际应用通常受到限制。然而，CMOS单光子雪崩二极管（SPAD）的最新进展使得能够以适合于实际应用的紧凑格式进行大规模多路复用时间相关单光子计数（TCSPC）。这项工作描述了我们努力采用这种技术来增强一系列技术，包括光纤光谱，内窥镜成像和宽场临床成像。
Single photon detection offers enhanced measurement through observation of timing dynamics on the picosecond to nanosecond scale. This has been widely exploited across many fields, including biological or medical technology. However practical application to clinic is often limited due to acquisition limitations of single point detectors combined with practical and cost limitations to employing larger numbers of detectors in combination. However, recent advancements in CMOS single photon avalanche diodes (SPADs) enable massively multiplexed time correlated single photon counting (TCSPC) in a compact format suitable for practical application. This work describes our efforts to employ this technology to enhance a range of technologies, including fibre optic spectroscopy, endoscopic imaging, and widefield clinical imaging.