KINETICS OF NUCLEATION-CONTROLLED POLYMERIZATION - A PERTURBATION TREATMENT FOR USE WITH A SECONDARY PATHWAY
KINETICS OF NUCLEATION-CONTROLLED POLYMERIZATION - A PERTURBATION TREATMENT FOR USE WITH A SECONDARY PATHWAY
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DOI：
10.1016/s0006-3495(84)84062-x
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发表时间：
1984-01-01
影响因子：
3.4
通讯作者：
FERRONE, FA
中科院分区：
文献类型：
--
作者：
BISHOP, MF;FERRONE, FA
本文提出了一种微扰法来分析由聚合物生长的第二途径增强的成核控制聚合反应。用这种方法，动力学方程的解假设一个简单的解析封闭形式，可以很容易地用于拟合数据。只要通过次级途径形成的聚合物线性地依赖于聚合的单体的浓度，溶液的形式是相同的。这允许分析扩增的增长模型与最小数量的建模假设，从而使它很容易区分各种次级过程（异质成核，横向生长和碎裂）。此外，均匀过程的参数，如均匀核的大小，可以确定独立的第二机制的性质。应用这种方法描述的肌动蛋白，胶原蛋白和镰状血红蛋白的聚合。肌动蛋白聚合的数据进行了广泛的分析，以说明使用的方法。横向生长描述的二级途径比原来提出的破碎模型。该方法可用于研究聚合物的聚合度、聚合物的母体以及聚合物在循环实验中的行为。
A perturbation method is presented for analyzing nucleation-controlled polymerization augmented by a secondary pathway for polymer growth. With this method, the solution to the kinetic equations assumes a simple analytic closed form that can easily be used in fitting data. So long as the formation of polymers by the secondary pathway depends linearly on the concentration of monomers polymerized, the form of the solutions is the same. This permits the analysis of augmented growth models with a minimum number of modeling assumptions, and thus makes it readily possible to distinguish between a variety of secondary processes (heterogeneous nucleation, lateral growth and fragmentation). In addition, the parameters of the homogeneous process, such as the homogeneous nucleus size, can be determined indpendent of the nature of the secondary mechanism. Applications of this method are described to the polymerization of actin, collagen and sickle Hb. An extensive analysis of data on actin polymerization is presented to illustrate the use of the method. Lateral growth describes the secondary pathway better than the fragmentation model originally proposed. This method can be used to study the degree of polymerization, the parentage of polymers and the behavior of polymers in cycling experiments.