An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds
An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds
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DOI：
10.1073/pnas.97.20.11026
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发表时间：
2000-09-26
影响因子：
11.1
通讯作者：
Ugurbil, K
中科院分区：
文献类型：
--
作者：
Ogawa, S;Lee, TM;Ugurbil, K
在本文中，我们展示了一种方法，通过该方法，一些诱发的神经元事件可以探测功能磁共振成像（fMRI）信号的时间分辨率在几十毫秒的时间尺度。该方法是基于神经元电事件和fMRI信号之间的密切关系，实验证明，在并发的fMRI和脑电图（EEG）在大鼠模型与前爪电刺激进行的研究。我们观察到一个不应期的神经元起源在两个刺激的范例：第一个刺激脉冲抑制诱发活动的EEG和fMRI信号响应于随后的刺激几百毫秒的时间。当有一个明显的网站网站的相互作用，检测诱发的EEG信号诱导的两个刺激，主要针对激活大脑中的两个不同的网站，功能磁共振成像也显示信号幅度调制，因为互动的事件。在人类大脑中使用两个短脉冲的视觉刺激，在初级视觉皮层的激活fMRI信号中观察到类似的不应现象。此外，对于短于由第一刺激诱发的诱发电位的已知潜伏期时间（近似100 ms）的刺激间间隔，在人脑的初级视觉皮层中，抑制不存在。因此，通过控制输入任务的时间关系。通过非侵入性的fMRI方法，可以在诱发电活动的时间尺度上研究某些神经事件的时间演变。
In this paper, we demonstrate an approach by which some evoked neuronal events can be probed by functional MRI (fMRI) signal with temporal resolution at the time scale of tens of milliseconds. The approach is based on the close relationship between neuronal electrical events and fMRI signal that is experimentally demonstrated in concurrent fMRI and electroencephalographic (EEG) studies conducted in a rat model with forepaw electrical stimulation. We observed a refractory period of neuronal origin in a two-stimuli paradigm: the first stimulation pulse suppressed the evoked activity in both EEG and fMRI signal responding to the subsequent stimulus for a period of several hundred milliseconds. When there was an apparent site-site interaction detected in the evoked EEG signal induced by two stimuli that were primarily targeted to activate two different sites in the brain, fMRI also displayed signal amplitude modulation because of the interactive event. With visual stimulation using two short pulses in the human brain, a similar refractory phenomenon was observed in activated fMRI signals in the primary visual cortex. In addition, for interstimulus intervals shorter than the known latency time of the evoked potential induced by the first stimulus (approximate to 100 ms) in the primary visual cortex of the human brain, the suppression was not present. Thus, by controlling the temporal relation of input tasks. it is possible to study temporal evolution of certain neural events at the time scale of their evoked electrical activity by noninvasive fMRI methodology.