Chemotherapy for colorectal cancer with a combination of PALA and 5-FU.
Chemotherapy for colorectal cancer with a combination of PALA and 5-FU.
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PALA 和 5-FU 联合化疗治疗结直肠癌。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
M. Valdivieso
中科院分区：
文献类型：
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作者：
A. Bedikian;J. Stroehlein;D. Karlin;R. Bennetts;G. Bodey;M. Valdivieso
51例未经治疗的晚期、可测量的结直肠癌患者被随机分成两组，分别接受单剂量PALA和5-FU治疗，每周(24名患者)或每天(27名患者)每4周治疗5天。在两个方案中，每日剂量的PALA静脉注射超过1小时，而5-FU的剂量静脉注射超过30分钟，从完成PALA剂量后3小时开始。根据毒性作用，两种药物的剂量同时发生变化。在接受每周方案评估的24名患者中有4名患者出现部分反应，在接受5天方案的26名患者中有3名患者出现部分反应。皮疹、黏膜炎和腹泻是两种治疗方案的限量毒性作用。这些毒性作用在高剂量和每周计划中更为常见和严重。骨髓抑制是轻度和中度的，本研究中使用的剂量和时间并没有显著增加5-FU的活性。没有必要进一步评估这些剂量和抗结直肠癌活动的时间表。
Fifty-one previously untreated patients with advanced, measurable colorectal cancer were randomized to receive single doses of PALA and 5-FU either weekly (24 patients) or daily for 5 days every 4 weeks (27 patients). In both schedules the daily dose of PALA was administered iv over 1 hour, while the dose of 5-FU was administered iv over 30 minutes, starting 3 hours after completion of the PALA dose. Doses of both drugs were changed simultaneously, based on toxic effects. Partial responses were seen in four of 24 evaluable patients receiving the weekly regimen and in three of 26 patients receiving the 5-day regimen. Skin rash, mucositis, and diarrhea were the dose-limiting toxic effects in both treatment regimens. These toxic effects were more common and severe at higher doses and on the weekly schedule. Myelosuppression was mild and moderate, the doses and schedules used in this study did not significantly increase the activity of 5-FU. Further evaluation of these doses and schedules for activity against colorectal cancer is not warranted.