The enantioselective intramolecular aminative functionalization of unactivated alkenes, dienes, allenes and alkynes for the synthesis of chiral nitrogen heterocycles.
The enantioselective intramolecular aminative functionalization of unactivated alkenes, dienes, allenes and alkynes for the synthesis of chiral nitrogen heterocycles.
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DOI：
10.1039/b907743j
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发表时间：
2009
影响因子：
3.2
通讯作者：
Chemler SR
中科院分区：
文献类型：
--
作者：
Chemler SR
未活化烯烃及相关π-体系的不对称选择性分子内胺化官能化反应是合成手性氮杂环化合物的一种直接且原子经济的策略。这些反应可以分类为氧化中性的，如烯烃加氢胺化，或氧化反应，如烯烃双官能化，例如氨基加氧和碳胺化。这一观点回顾了该领域目前的工作，并探讨了不同催化剂和反应类型之间常见的机理趋势。
The enantioselective intramolecular aminative functionalization of unactivated alkenes and related π-systems is a straight-forward and atom economical strategy for the synthesis of chiral nitrogen heterocycles. These reactions can be categorized as oxidatively neutral, such as alkene hydroamination, or as oxidative reactions, such as alkene difunctionalization, e.g. aminooxygenation and carboamination. This perspective reviews the current work in the field and explores mechanistic trends that are common among the different catalysts and reaction types.