FROM PARASITES TO ALLERGY - A 2ND RECEPTOR FOR IGE
FROM PARASITES TO ALLERGY - A 2ND RECEPTOR FOR IGE
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DOI：
10.1016/0167-5699(86)90184-2
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发表时间：
1986-01-01
期刊：
影响因子：
--
通讯作者：
TONNEL, AB
中科院分区：
文献类型：
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作者：
CAPRON, A;DESSAINT, JP;TONNEL, AB
当肥大细胞结合IgE抗体时，触发人类过敏反应。IgE的产生也是蠕虫感染的一个常规特征，并且寄生虫可以被反应素抗体致敏的炎性细胞如巨噬细胞、嗜酸性粒细胞和血小板杀死。它们使用的IgE受体最近才被发现。在这里，Andre Capron和他的同事讨论了它与肥大细胞上的IgE受体的不同之处。在过去的十年中，抗体依赖性细胞毒性（ADCC）是对抗几种蠕虫寄生虫的主要防御机制1-3。引人注目的是，炎性细胞，如巨噬细胞、嗜酸性粒细胞和血小板，而不是淋巴样细胞，是杀灭寄生虫的活性细胞伴侣，通常与速发型超敏反应相关的同种型似乎是所涉及的必需抗体（图1）。
Human allergic responses are triggered when mast cells bind IgE antibodies. IgE production is also a regular feature of helminth infection and parasites can be killed by inflammatory cells such as macrophages, eosinophils and platelets sensitized by reaginic antibody. The IgE receptor they use has been identified only recently. Here Andre Capron and his colleagues discuss how it differs from the IgE receptor present on mast cells.In the past decade it has become clear that antibody-dependent cellular cytotoxicity (ADCC) is a primary defence mechanism against several helminth parasites 1-3. Strikingly, inflammatory cells, such as macrophages, eosinophils and platelets, rather than lymphoid cells, are the active cellular partners in parasite killing, and isotypes usually associated with immediate-type hypersensitivity reactions appear to be the essential antibodies involved (Fig. 1).