Inheritance of susceptibility to caries in albino rats (Mus norvegicus)
Inheritance of susceptibility to caries in albino rats (Mus norvegicus)
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DOI：
10.1177/00220345440230051101
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发表时间：
1944-01-01
期刊：
影响因子：
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通讯作者：
Erwin, W. G.
中科院分区：
文献类型：
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作者：
Hunt, H. R.;Hoppert, C. A.;Erwin, W. G.
采用Hoppert、Webber和Canniff三种龋齿生产食谱，对大鼠龋齿易感性进行了遗传学研究。表型选择、后代测试和兄弟姐妹近亲交配产生了一株感病和一株抗病的品系。本报告包括11代敏感家鼠(1357只)和6代抗性家鼠(1193只)。抵抗力是通过从开始摄入上述饮食(35d龄)到出现下磨牙第一颗龋齿的天数来衡量的。兄弟姐妹的大小可能会影响平均绩效，除非在计算中消除这一因素。确保了每个兄弟姐妹的平均阻力，然后是平均阻力。一代人中这些兄弟姐妹关系的平均值是计算出来的。平均。第7代敏感品系的亲缘关系平均值为38天，抗性品系为245天。差值(207天)的t=7.31。这种差异的可能性超过2,000,000比1。因此，在饮食保持不变的情况下，大鼠在龋齿方面可以表现出遗传差异。||摘要作者：H.R.亨特
A genetic study of susceptibility to dental caries in rats was made, using the Hoppert, Webber, and Canniff caries producing diet. Phenotypic selection, progeny testing, and brother X sister inbreeding have produced a susceptible and a resistant line. Eleven generations of the susceptibles (1357 rats), and 6 generations of resistants (1193 rats), are included in this report. Resistance was measured by days elapsing from introduction to the above diet (at 35 days of age), to the appearance of the first cavities in the lower molars. Sizes of sibships might have influenced average performance unless this factor was eliminated in computation. The mean resistance of each sibship was secured, then the avg. of these sibship means in a generation was computed. The avg. of sibship means in the 7th generation of susceptibles was 38 days, of the resistants 245 days. The t value of the difference (207 days) was 7.31. The odds against this difference being due to chance exceed 2,000,000 to 1. Thus with diet held constant, hereditary differences can be demonstrated in rats with respect to dental caries. || ABSTRACT AUTHORS: H. R. Hunt