Duration of untreated illness as a predictor of treatment response and clinical course in generalized anxiety disorder
Duration of untreated illness as a predictor of treatment response and clinical course in generalized anxiety disorder
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DOI：
10.1017/s1092852900016588
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发表时间：
2008-05-01
期刊：
影响因子：
3.3
通讯作者：
Mundo, Emanuela
中科院分区：
文献类型：
--
作者：
Altamura, A. Carlo;Dell'Osso, Bernardo;Mundo, Emanuela
简介：本研究的目的是调查未治疗疾病持续时间（DUI）的影响——定义为广泛性焦虑症（GAD）发病与第一次充分药物治疗之间的时间间隔，对 GAD 受试者样本的治疗反应和临床病程。方法：纳入了 100 名根据《精神疾病诊断与统计手册》第四版文本修订标准诊断的 GAD 患者，并收集了他们的主要人口统计学和临床特征。然后，患者在开放标签条件下接受选择性血清素再摄取抑制剂或文拉法辛治疗 8 周。根据 DUI（DUI 12 个月）将样本分为两组后，分析治疗反应和其他临床变量。 结果：当相对于第一次抗抑郁治疗（DUI-AD）计算 DUI 时，在 DUI 较短的组中发现药物治疗后有更高的改善（临床总体印象 - 疾病严重程度）（重复测量的方差分析：时间效应 F=654.975，P
Introduction: The aim of the present study was to investigate the impact of the duration of untreated illness (DUI)-defined as the time elapsing between the onset of generalized anxiety disorder (GAD) and the first adequate pharmacologic treatment-on treatment response and clinical course in a sample of subjects with GAD.Methods: One hundred patients with GAD, diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-Text Revision criteria, were enrolled and their main demographic and clinical features collected. Patients were then treated with selective serotonin reuptake inhibitors or venlafaxine for 8 weeks in open-label conditions. Treatment response and other clinical variables were analyzed after dividing the sample into two groups according to DUI (DUI 12 months).Results: When the DUI was computed with respect to the first antidepressant treatment (DUI-AD), a higher improvement (Clinical Global Impressions-Severity of Illness scale) after the pharmacologic treatment was found in the group with a shorter DUI (analysis of variance with repeated measures: time effect F=654.975, P