Erythema multiforme, Stevens Johnson syndrome, and toxic epidermal necrolysis reported after vaccination, 1999-2017
Erythema multiforme, Stevens Johnson syndrome, and toxic epidermal necrolysis reported after vaccination, 1999-2017
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DOI：
10.1016/j.vaccine.2019.12.028
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发表时间：
2020-02-11
期刊：
影响因子：
5.5
通讯作者：
Cano, Maria, V
中科院分区：
文献类型：
--
作者：
Su, John R.;Haber, Penina;Cano, Maria, V
背景：自从上次对多形红斑（EM）、史蒂文斯·约翰逊综合征（SJS）、SJS/TEN和中毒性表皮坏死松解症（EM/SJS/TEN）的疫苗安全性监测数据进行审查以来，美国已经引入了37多种新疫苗。我们试图描述1999-2017年期间接种疫苗后报告的EM/SJS/TEN。方法：我们收集了1999-2017年期间疫苗不良事件报告系统（VAERS）收到的美国EM/SJS/TEN报告。我们按病情（EM、SJS或TEN）进行分层分析，并按严重或非严重状态、性别、年龄组、从接种疫苗到症状出现的时间、暴露于EM/SJS/TEN的已知原因以及接种疫苗进行分析。我们使用经验贝叶斯数据挖掘来检测比预期更频繁报告的疫苗- ae对。结果：在1999-2017年期间向VAERS提交的466,027份报告中，我们确定了984份EM报告，89份SJS报告，6份SJS/TEN报告和7份TEN报告。EM报告少（9%），SJS报告多（52%），SJS/TEN（100%）和TEN（100%）严重。总体而言，55%的报告描述了男性，48%的报告描述了4岁以下的儿童；EM/SJS/TEN发生率为58%
Background: Since the last review of vaccine safety surveillance data for erythema multiforme (EM), Stevens Johnson syndrome (SJS), SJS/TEN, and toxic epidermal necrolysis (TEN) (EM/SJS/TEN), over 37 new vaccines have been introduced in the United States. We sought to describe reported EM/SJS/TEN after vaccines during 1999-2017.Methods: We identified U.S. reports of EM/SJS/TEN received by the Vaccine Adverse Event Reporting System (VAERS) during 1999-2017. We stratified analysis by condition (EM, SJS, or TEN), and analyzed reports by serious or non-serious status, sex, age group, time from vaccination to symptom onset, exposure to known causes of EM/SJS/TEN, and vaccines administered. We used Empirical Bayesian data mining to detect vaccine-AE pairs reported more frequently than expected.Results: Of 466,027 reports to VAERS during 1999-2017, we identified 984 reports of EM, 89 reports of SJS, 6 reports of SJS/TEN, and 7 reports of TEN. Few reports of EM (9%), and most reports of SJS (52%), SJS/TEN (100%), and TEN (100%) were serious. Overall, 55% of reports described males, 48% described children aged < 4 years; 58% of EM/SJS/TEN occurred