T-CELLS IN REGENERATING FEATHERS OF SMYTH LINE CHICKENS WITH VITILIGO
T-CELLS IN REGENERATING FEATHERS OF SMYTH LINE CHICKENS WITH VITILIGO
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DOI：
10.1006/clin.1995.1105
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发表时间：
1995-08-01
期刊：
影响因子：
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通讯作者：
SMYTH, JR
中科院分区：
文献类型：
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作者：
ERF, GF;TREJOSKALLI, AV;SMYTH, JR
Smyth系（SL）鸡在再生羽毛组织中由于色素细胞（黑素细胞）死亡而表现出自发的自身免疫性色素沉着（SL白癜风，SLV）。这是本研究的目的，以表征单核白细胞浸润羽毛随着SLV的发展。用鸡单核白细胞特异性单克隆抗体标记SL鸡和对照鸡再生羽毛的冷冻切片，发现SL鸡在SLV发育之前和整个发育过程中羽毛浆中的T细胞数量显著增加。最初，SL鸡和对照鸡的羽浆CD4/CD8比值均接近1.0。SLV发病后，SL鸡的CD4/CD8比值降至0.4以下。在SLV发育过程中，与对照组相比，SL鸡具有更高比例的α / β T细胞受体的T细胞。组织学证据有力地支持T细胞在SLV病理中的重要作用。(C) 1995学术出版社，Inc。
Smyth line (SL) chickens exhibit a spontaneous, autoimmune, depigmentation (SL vitiligo, SLV) in regenerating feather tissue due to the death of pigment cells (melanocytes). It was the purpose of this study to characterize mononuclear leukocytes which infiltrate the feather as SLV develops. Frozen sections of regenerating feathers from SL and control chickens were labeled with a panel of mAbs specific for chicken mononuclear leukocytes, SL chickens were found to have significantly greater numbers of T cells in the feather pulp prior to, and throughout, the development of SLV. Initially, both SL and control chickens had a CD4/CD8 ratio near 1.0 in their feather pulp. Following the onset of SLV, the CD4/CD8 ratio in SL chickens dropped below 0.4. Throughout the development of SLV, SL chickens had greater proportions of T cells with alpha/beta T cell receptors than controls. Histological evidence strongly supports an important role for T cells in the pathology of SLV. (C) 1995 Academic Press, Inc.