Automated single-trial assessment of laser-evoked potentials as an objective functional diagnostic tool for the nociceptive system
Automated single-trial assessment of laser-evoked potentials as an objective functional diagnostic tool for the nociceptive system
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DOI：
10.1016/j.clinph.2012.05.007
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发表时间：
2012-12-01
影响因子：
4.7
通讯作者：
Mouraux, A.
中科院分区：
文献类型：
--
作者：
Hatem, S. M.;Hu, L.;Mouraux, A.
目的：目的：探讨事件相关电位（ERPs）自动分析的临床应用价值。方法：对37例脊髓损伤患者和21例正常对照者进行伤害性激光诱发电位（LEPs）和非伤害性体感电诱发电位（SEPs）检测。LEP和SEP的峰值幅度和潜伏期估计使用单次试验自动化的方法时频小波滤波和多元线性回归，以及传统的方法的基础上，目视investment.Results：正常和异常LEP和SEP峰的幅度和潜伏期可靠地确定使用两种方法，具有相似的敏感性和特异性。由于自动化的方法提供了一个公正的解决方案，占平均波形没有ERP可以识别视觉，它揭示了显着差异患者和对照组，没有透露使用visual approach.Conclusion：ERP的自动化分析特征可靠和客观的LEP和SEP波形的患者。自动单次试验分析可用于表征正常和异常ERP，其灵敏度和特异性与目视检查相似。虽然这并不能证明其在常规临床环境中的使用是合理的，但该技术可能有助于避免临床研究中的药物依赖性偏倚。(C)2012年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To assess the clinical usefulness of an automated analysis of event-related potentials (ERPs).Methods: Nociceptive laser-evoked potentials (LEPs) and non-nociceptive somatosensory electrically-evoked potentials (SEPs) were recorded in 37 patients with syringomyelia and 21 controls. LEP and SEP peak amplitudes and latencies were estimated using a single-trial automated approach based on time-frequency wavelet filtering and multiple linear regression, as well as a conventional approach based on visual inspection.Results: The amplitudes and latencies of normal and abnormal LEP and SEP peaks were identified reliably using both approaches, with similar sensitivity and specificity. Because the automated approach provided an unbiased solution to account for average waveforms where no ERP could be identified visually, it revealed significant differences between patients and controls that were not revealed using the visual approach.Conclusion: The automated analysis of ERPs characterized reliably and objectively LEP and SEP waveforms in patients.Significance: The automated single-trial analysis can be used to characterize normal and abnormal ERPs with a similar sensitivity and specificity as visual inspection. While this does not justify its use in a routine clinical setting, the technique could be useful to avoid observer-dependent biases in clinical research. (C) 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.