Real-time sonoelastography performed in addition to B-mode ultrasound and mammography:: Improved differentiation of breast lesions?
Real-time sonoelastography performed in addition to B-mode ultrasound and mammography:: Improved differentiation of breast lesions?
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DOI：
10.1016/j.acra.2006.08.012
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发表时间：
2006-12-01
影响因子：
4.8
通讯作者：
Fischer, Thomas
中科院分区：
文献类型：
--
作者：
Thomas, Anke;Kuemmel, Sherko;Fischer, Thomas
基本原理和目标。本研究的目的是比较弹性成像与b超（US）和乳房x线摄影的敏感性和特异性。材料与方法。共纳入300例组织学证实的乳腺病变患者（168例为良性，132例为恶性）。采用三维有限元法进行评价。这些数据是彩色编码的，并叠加在b型超声扫描上。图像由两名独立的阅读者进行评估。结果与乳房x线摄影，组织学和先前美国调查获得的数据进行比较。计算敏感性和特异性。乳腺x线检查鉴别良恶性病变的敏感性和特异性分别为87%和85%，b型超声检查的敏感性和特异性分别为94%和83%。两位审查员对弹性图的评价非常一致（kappa: 0.86）。弹性成像的敏感性为82%，特异性为87%。弹性成像在诊断乳腺成像报告和数据系统（BI-RADS） 3病变（92%比82%特异性）和脂肪瘤累及（80%比69%特异性）方面优于b超超声。与b超相比，弹性成像在乳腺病变中的特异性更高，敏感性较低。弹性成像可能对BI-RADS 3型病变和脂肪瘤复发有益。
Rationale and Objectives. The goal of the present study was to compare the sensitivity and specificity of elastography with that of B-mode ultrasound (US) and mammography.Materials and Methods. A total of 300 patients with histologically confirmed breast lesions (168 benign, 132 malignant) were included. Evaluation was by means of the three-dimensional finite-element method. The data are color-coded and superimposed on the B-mode US scan. The images were evaluated by two independent readers. The results were compared with mammography, histology, and the data obtained by previous US investigations. Sensitivities and specificities were calculated.Results. Sensitivity and specificity in the differentiation of benign and malignant lesions were 87% and 85%, respectively, for mammography and 94% and 83% for B-mode US. The two examiners were in very good agreement in their evaluation of the elastograms (kappa: 0.86). Elastography had a sensitivity of 82% and a specificity of 87%. Elastography was superior to B-mode US in diagnosing Breast Imaging Reporting and Data System (BI-RADS) 3 lesions (92% vs. 82% specificity) and in lipomatous involution (80% vs. 69% specificity).Conclusion. Elastography in breast lesions showed a higher specificity and a lower sensitivity in comparison with B-mode sonography. Elastography may be beneficial in BI-RADS 3 lesions and in lipomatous involution.