Profile of renal AA amyloidosis in older and younger individuals: a single-centre experience
Profile of renal AA amyloidosis in older and younger individuals: a single-centre experience
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DOI：
10.1080/13506129.2018.1474733
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发表时间：
2018-01-01
影响因子：
5.5
通讯作者：
Keven, Kenan
中科院分区：
文献类型：
--
作者：
Erdogmus, Siyar;Celebi, Zeynep Kendi;Keven, Kenan
目的：对土耳其A型淀粉样蛋白（AA）淀粉样变的流行病学研究发现，家族性地中海热（FMF）是最常见的病因，常见于青年人群。然而，关于老年患者肾AA淀粉样变的病因、临床表现和预后尚无足够的资料。在这项研究中，我们的目的是调查60岁或以上活检证实的肾AA淀粉样变患者的人口统计学、临床表现、病因学和结局。方法：对2006年至2016年经肾活检诊断为AA淀粉样变的53例患者进行回顾性研究。所有患者均因无症状蛋白尿、肾病综合征和/或肾功能不全而行肾活检。患者按年龄分为两组（I组：60岁；II组：60岁）。
Objective: In epidemiological studies of amyloid A (AA) amyloidosis from Turkey, the most frequently cause was familial Mediterranean fever (FMF) and it occurs generally in young age population. However, there are no sufficient data regarding aetiology, clinical presentation and prognosis of renal AA amyloidosis in advanced age patients. In this study, we aimed to investigate demographic, clinical presentation, aetiology and outcomes of adults aged 60 years or older patients with biopsy-proven renal AA amyloidosis.Methods: This is a retrospective study involving 53 patients who were diagnosed with AA amyloidosis by kidney biopsy from 2006 to 2016. In all patients, kidney biopsies were performed due to asymptomatic proteinuria, nephrotic syndrome and/or renal insufficiency. The patients were separated into two groups on the basis of age (group I: 60 years and group II: