High resolution morphologic imaging and T2 mapping of cartilage at 7 Tesla: comparison of cartilage repair patients and healthy controls
High resolution morphologic imaging and T2 mapping of cartilage at 7 Tesla: comparison of cartilage repair patients and healthy controls
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DOI：
10.1007/s10334-013-0379-2
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发表时间：
2013-12-01
影响因子：
2.3
通讯作者：
Regatte, Ravinder R.
中科院分区：
文献类型：
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作者：
Chang, Gregory;Xia, Ding;Regatte, Ravinder R.
我们的目的是使用7 T MRI比较软骨修复患者和健康对照组的软骨形态（厚度）和胶原成分（T2值）。我们在7 T MRI扫描仪上扫描了11名软骨修复患者和11名对照组的膝关节，使用高分辨率梯度回波序列测量软骨厚度，使用多回波自旋回波序列测量软骨T2值。我们使用双尾t检验来比较软骨厚度和T2值：修复组织（RT）与邻近软骨（AC）; RT与健康对照软骨（HC）; AC与HC。RT、AC、HC的平均厚度为：2.2 +/- A 1.4，3.6 +/- A 1.1，3.3 +/- A 0.7 mm。RT-AC（p = 0.01）和RT-HC（p = 0.02）之间的厚度差异具有显著性，但AC-HC（p = 0.45）之间的差异不显著。RT、AC、HC的平均T2值为：51.6 +/- A 7.6，40.0 +/- A 4.7，45.9 +/- A 3.7 ms。RT-AC之间T2值的差异（p = 0.0005），RT-HC（p = 0.04）和AC-HC（p = 0.004）具有显著性。7 T MRI允许检测以下方面的形态学和胶原结构差异：（1）与邻近软骨相比的软骨修复组织和（2）与来自健康对照的软骨相比的软骨修复组织。虽然邻近修复组织的软骨厚度可能是正常的，但它可以表现出改变的胶原蛋白组成。
Our objective was to use 7 T MRI to compare cartilage morphology (thickness) and collagen composition (T2 values) in cartilage repair patients and healthy controls.We scanned the knees of 11 cartilage repair patients and 11 controls on a 7 T MRI scanner using a high-resolution, gradient-echo sequence to measure cartilage thickness and a multi-echo spin-echo sequence to measure cartilage T2 values. We used two-tailed t tests to compare cartilage thickness and T2 values in: repair tissue (RT) versus adjacent cartilage (AC); RT versus healthy control cartilage (HC); AC versus HC.Mean thickness in RT, AC, HC were: 2.2 +/- A 1.4, 3.6 +/- A 1.1, 3.3 +/- A 0.7 mm. Differences in thickness between RT-AC (p = 0.01) and RT-HC (p = 0.02) were significant, but not AC-HC (p = 0.45). Mean T2 values in RT, AC, HC were: 51.6 +/- A 7.6, 40.0 +/- A 4.7, 45.9 +/- A 3.7 ms. Differences in T2 values between RT-AC (p = 0.0005), RT-HC (p = 0.04), and AC-HC (p = 0.004) were significant.7 T MRI allows detection of differences in morphology and collagen architecture in: (1) cartilage repair tissue compared to adjacent cartilage and (2) cartilage repair tissue compared to cartilage from healthy controls. Although cartilage adjacent to repair tissue may be normal in thickness, it can demonstrate altered collagen composition.