The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists
The anti-inflammatory and immunological properties of GLP-1 Receptor Agonists
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DOI：
10.1016/j.phrs.2022.106320
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发表时间：
2022-08-01
影响因子：
9.3
通讯作者：
Fiorina, Paolo
中科院分区：
文献类型：
--
作者：
Bendotti, Giulia;Montefusco, Laura;Fiorina, Paolo
在过去的几年里，人们对胰高血糖素样肽-1受体激动剂（GLP-1RAs）的多效性研究产生了极大的兴趣。虽然GLP-1RAs降低血糖和诱导体重减轻的能力使其被批准用于治疗糖尿病和肥胖症，但体外研究和临床前模型的一致证据表明，GLP-1RAs具有抗炎特性，并可能调节免疫系统。值得注意的是，这种抗炎作用针对不同组织的不同途径，支持GLP-1RAs的广谱作用。本文综述了目前提出的GLP-1RAs作用的一些分子机制，并探讨了它们在减少炎症反应方面的潜在益处，这可能会为GLP-1RAs在未来治疗新适应症中的应用提供建议。
In the last few years, a great interest has emerged in investigating the pleiotropic effects of Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs). While GLP-1RAs ability to lower plasma glucose and to induce weight loss has allowed them to be approved for the treatment of diabetes and obesity, consistent evidences from in vitro studies and preclinical models suggested that GLP-1RAs have anti-inflammatory properties and that may modulate the immune-system. Notably, such anti-inflammatory effects target different pathways in different tissues, underling the broad spectrum of GLP-1RAs actions. This review examines some of the currently proposed molecular mechanisms of GLP-1RAs actions and explores their potential benefits in reducing inflammatory responses, which may well suggest a future therapeutic use of GLP-1RAs in new indications.