Evaluation of oral air space volume in obstructive sleep apnea syndrome using clinical and postmortem CT imaging
Evaluation of oral air space volume in obstructive sleep apnea syndrome using clinical and postmortem CT imaging
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使用临床和死后 CT 成像评估阻塞性睡眠呼吸暂停综合征的口腔空气体积
DOI：
10.1007/s11282-021-00520-y
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发表时间：
2022
期刊：
影响因子：
2.2
通讯作者：
Kazuyuki Minowa owa
中科院分区：
文献类型：
--
作者：
Akiko Takeuchi;Hideki Hyodoh;Kotaro Matoba;Manabu Murakami;Kohsuke Kudo;Kazuyuki Minowa owa
目的阻塞性睡眠呼吸暂停综合征（OSAS）是上呼吸道阻塞性疾病，可引起睡眠期猝死。方法（1）将50例OSAS患者随机分为OSAS组（25例）和对照组（25例）。(2)来自临床病例的28名受试者分为两组：OSAS组（9名受试者）和对照组（19名受试者）。所有病例均行面部CT扫描，分析死亡病例和临床病例口腔面积容积的4个参数，并与对照组进行比较分析。结果（1）死亡病例的口腔软组织体积（OSV）、口腔气腔体积（OAV）、OAV/OSV比值（%air）均呈显著相关; (2)在临床病例中，OAV和%air显示出显著相关性。在尸检和临床图像中，一个小的%空气值表明发展OSAS的高风险和高概率的OSAS-related猝死.ConclusionsIt表明，%空气是一个指标，以评估OSAS的口腔区域的CT成像。当死亡病例的%air值为16.0%时，临床病例的%air值为16.6%时，可指示OSAS。
ObjectivesObstructive sleep apnea syndrome (OSAS) induces upper airway occlusion and may cause sudden death during sleep. This study sought to clarify the relationship between oral air space volume and OSAS onset, which is influenced by multiple factors, such as jawbone, dentition morphology, and oral soft-tissue volume.Methods(1) 50 subjects from deceased cases were divided into two groups: OSAS (25 subjects) and controls (25 subjects). (2) 28 subjects from clinical cases were divided into two groups: OSAS (9 subjects) and controls (19 subjects). In all cases, the Computed Tomography (CT) images of the facial region were obtained, and four parameters of oral area volume were analyzed in deceased and clinical cases, and comparisons and analyses were performed between OSAS and control cases. In addition, the efficiency of measurement of these parameters was evaluated using Receiver Operating Characteristic (ROC) curves in OSAS.Results(1) In deceased cases, oral soft-tissue volume (OSV), oral air-space volume (OAV), and the ratio of OAV to OSV (%air) showed a significant correlation. (2) In clinical cases, OAV and %air showed a significant correlation. In both postmortem and clinical images, a small %air value indicates a high risk of developing OSAS and a high probability of OSAS-related sudden death.ConclusionsIt was shown that the %air is an index to evaluate OSAS by CT imaging of the oral region. OSAS may be indicated when the %air value is ≦ 16.0% in deceased cases and ≦ 6.6% in clinical cases.