Transcranial alternating current stimulation at 10 Hz modulates response bias in the Somatic Signal Detection Task
Transcranial alternating current stimulation at 10 Hz modulates response bias in the Somatic Signal Detection Task
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DOI：
10.1016/j.ijpsycho.2018.12.001
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发表时间：
2019-01-01
影响因子：
3
通讯作者：
Lloyd, Donna
中科院分区：
文献类型：
--
作者：
Craddock, Matt;Klepousniotou, Ekaterini;Lloyd, Donna
在8-13 Hz α范围内的持续的刺激前振荡活动已被证明与阈值附近体感刺激的真实和虚假报告相关。然而，为了直接测试这种振荡活动在行为中的作用，有必要对其进行操纵。经颅交流电刺激（tACS）提供了一种使用传递到头皮的正弦电流直接操纵振荡脑活动的方法。我们测试了α-tACS是否会改变体感灵敏度或信号检测任务中的反应偏差，以测试α-振荡是否在行为中具有因果作用。使用双侧放置在10-20电极放置系统的位置CP 3和CP 4处的电极施加主动10 Hz tACS或假刺激。参与者执行躯体信号检测任务（SSDT），在该任务中，他们必须检测到在其检测阈值处传递的简短躯体感觉目标。这些目标有时伴随着闪光，也可能单独发生。活性tACS不调节对靶点的敏感性，但调节应答标准。具体来说，我们发现主动刺激通常会增加触摸报告率，但特别是增加对光照试验的反应。刺激与触摸的存在没有相互作用，因此增加了命中和误报。TAGS刺激增加了触摸的报告，与我们的观察报告一致，改变反应偏差，并与α活动在体感检测中的作用一致。
Ongoing, pre-stimulus oscillatory activity in the 8-13 Hz alpha range has been shown to correlate with both true and false reports of peri-threshold somatosensory stimuli. However, to directly test the role of such oscillatory activity in behaviour, it is necessary to manipulate it. Transcranial alternating current stimulation (tACS) offers a method of directly manipulating oscillatory brain activity using a sinusoidal current passed to the scalp. We tested whether alpha tACS would change somatosensory sensitivity or response bias in a signal detection task in order to test whether alpha oscillations have a causal role in behaviour. Active 10 Hz tACS or sham stimulation was applied using electrodes placed bilaterally at positions CP3 and CP4 of the 10-20 electrode placement system. Participants performed the Somatic Signal Detection Task (SSDT), in which they must detect brief somatosensory targets delivered at their detection threshold. These targets are sometimes accompanied by a light flash, which could also occur alone. Active tACS did not modulate sensitivity to targets but did modulate response criterion. Specifically, we found that active stimulation generally increased touch reporting rates, but particularly increased responding on light trials. Stimulation did not interact with the presence of touch, and thus increased both hits and false alarms. TAGS stimulation increased reports of touch in a manner consistent with our observational reports, changing response bias, and consistent with a role for alpha activity in somatosensory detection.