Host Immune Responses to Clostridioides difficile Infection and Potential Novel Therapeutic Approaches.
Host Immune Responses to Clostridioides difficile Infection and Potential Novel Therapeutic Approaches.
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DOI：
10.3390/tropicalmed8120506
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发表时间：
2023-11-23
影响因子：
2.9
通讯作者：
Fallon JT
中科院分区：
文献类型：
--
作者：
Alam MZ;Markantonis JE;Fallon JT
艰难梭菌感染（CDI）是一种主要的医院感染，在美国和全球范围内构成了重大的公共卫生挑战。CDI通常发生在已使用抗生素的住院老年患者中;然而，社区中未暴露于抗生素的年轻人中CDI的发生率有所上升。C.艰难梭菌释放毒素，破坏大肠上皮，导致中毒性巨结肠、败血症，甚至死亡。不幸的是，现有的抗生素疗法并不总是能预防这些后果，多达三分之一的治疗患者会出现感染复发。宿主因素在CDI的发病机制中起着至关重要的作用，越来越多的证据表明，宿主免疫反应的调节可能会改变疾病的结局。在这篇综述中，我们概述了我们目前关于先天性和适应性免疫反应对CDI结果的作用的知识。此外，我们提出了一个总结的非抗生素微生物为基础的治疗，可以有效地影响宿主的免疫反应，沿着的免疫策略，旨在解决治疗和预防CDI。
Clostridioides difficile infection (CDI) is a leading nosocomial infection, posing a substantial public health challenge within the United States and globally. CDI typically occurs in hospitalized elderly patients who have been administered antibiotics; however, there has been a rise in the occurrence of CDI in the community among young adults who have not been exposed to antibiotics. C. difficile releases toxins, which damage large intestinal epithelium, leading to toxic megacolon, sepsis, and even death. Unfortunately, existing antibiotic therapies do not always prevent these consequences, with up to one-third of treated patients experiencing a recurrence of the infection. Host factors play a crucial role in the pathogenesis of CDI, and accumulating evidence shows that modulation of host immune responses may potentially alter the disease outcome. In this review, we provide an overview of our current knowledge regarding the role of innate and adaptive immune responses on CDI outcomes. Moreover, we present a summary of non-antibiotic microbiome-based therapies that can effectively influence host immune responses, along with immunization strategies that are intended to tackle both the treatment and prevention of CDI.
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影响因子：
5.8
作者：
Collins, Laura E.;Lynch, Mark;Loscher, Christine E.
通讯作者：
Loscher, Christine E.
影响因子：
2.3
作者：
Bruxelle, J. -F.;Mizrahi, A.;Pechine, S.
通讯作者：
Pechine, S.
影响因子：
5.1
作者：
Cotter, Jillian M.;Thomas, Jacob;Dominguez, Samuel R.
通讯作者：
Dominguez, Samuel R.
影响因子：
4.6
作者：
Carlucci, Christian;Jones, Carys S.;Allen-Vercoe, Emma
通讯作者：
Allen-Vercoe, Emma
基于粪便的菌群菌群疗法，用于复发性艰难梭菌感染，溃疡性结肠炎和肥胖症。
影响因子：
11.1
作者：
Carlucci C;Petrof EO;Allen-Vercoe E
通讯作者：
Allen-Vercoe E