Ventricular volume and asymmetry in schizotypal personality disorder and schizophrenia assessed with magnetic resonance imaging
Ventricular volume and asymmetry in schizotypal personality disorder and schizophrenia assessed with magnetic resonance imaging
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DOI：
10.1016/s0920-9964(97)00087-x
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发表时间：
1997-10-17
影响因子：
4.5
通讯作者：
Siever, LJ
中科院分区：
文献类型：
--
作者：
Buchsbaum, MS;Yang, S;Siever, LJ
对12例典型人格障碍（SPD）患者、11例慢性精神分裂症患者和23例年龄、性别匹配的正常志愿者进行了磁共振成像（MRI）检查。在轴向平面上以1.2 mm的间隔采集MRI切片，并在每隔一个切片上追踪心室。侧脑室系统分为前角、颞角和背侧脑室。精神分裂症患者的左前角和颞角比正常志愿者大。SPD患者左前角和颞角的大小介于正常志愿者和精神分裂症患者之间，与精神分裂症患者有显著差异。精神分裂症患者的左减右差大于正常志愿者或SPD患者。因此，在他们的大脑结构特征，以及在他们的临床精神病学，SPD患者的证据，在减弱的形式，异常类似于那些发现在完全的精神分裂症。研究结果表明，减少左半球体积，在额叶和颞叶地区，可能是精神分裂症谱的精神病和非精神病性障碍的特点。(C)1997年Elsevier Science B.V.
Magnetic resonance imaging (MRI) was performed in 12 patients with schizotypal personality disorder (SPD), 11 patients with chronic schizophrenia, and 23 age- and sex-matched normal volunteers. MRI slices were acquired in the axial plane at 1.2-mm intervals, and the ventricles were traced on every other slice. The lateral ventricular system was divided into the anterior horn, temporal horn, and dorsal lateral ventricle. Schizophrenic patients had larger left anterior and temporal horns than the normal volunteers. Size of the left anterior and temporal horn in SPD patients was intermediate between those of normal volunteers and schizophrenic patients and differed significantly from schizophrenic patients. The left-minus-right difference was larger in schizophrenic patients than in normal volunteers or SPD patients. Thus, in their structural brain characteristics, as well as in their clinical symptomatology, SPD patients evidence, in attenuated form, abnormalities resembling those found in full-ledged schizophrenia. The findings suggest that decreased left hemispheric volume, in frontal and temporal regions, may characterize both psychotic and non-psychotic disorders of the schizophrenia spectrum. (C) 1997 Elsevier Science B.V.