Migration and multiple sclerosis in United Kingdom and Ireland immigrants to Australia: a reassessment. II. Characteristics of early (pre-1947) compared to later migrants
Migration and multiple sclerosis in United Kingdom and Ireland immigrants to Australia: a reassessment. II. Characteristics of early (pre-1947) compared to later migrants
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DOI：
10.1007/s00415-011-6244-1
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发表时间：
2012-04-01
影响因子：
6
通讯作者：
Kurtzke, J. F.
中科院分区：
文献类型：
--
作者：
McLeod, J. G.;Hammond, S. R.;Kurtzke, J. F.
在我们最近的重新评估中，我们研究了1947-1981年间从英国和爱尔兰(UKI)移民到澳大利亚四个州(新南威尔士州、昆士兰州、南澳大利亚州和西澳大利亚州)的258名移民的年龄多发性硬化症的风险(第二组)。在本报告中，我们将他们的特征与1947年之前迁徙的44例病例(组I)进行了比较，分为两个亚组：组I(15例)在移民年龄(平均20岁和23岁)、发病年龄(39岁和33岁)以及从移民到发病的时间(19岁和10岁)方面与组II非常相似。Ib组(29例)与II组显著不同，移民时的平均年龄为4岁，发病时的平均年龄为40岁，从移民到发病的平均间隔约为35年。Ib组的所有起病都发生在1947年之后。我们得出结论，Ib组病例最有可能在澳大利亚获得多发性硬化症。1947年之前，来自包括英国在内的多发性硬化症高危国家的移民人数并不多，但在1947-1981年期间，大约有77万人进入。他们可能是Ib组移民多发性硬化症的来源。
In our recent reassessment we explored the risk of MS by age at immigration in 258 migrants from United Kingdom and Ireland (UKI) to four states of Australia (New South Wales, Queensland, South Australia, and Western Australia) in the period 1947-1981 (Group II). In the present report we have compared their characteristics with 44 cases who migrated before 1947 (Group I), divided into two subsets: Group Ia (15 cases) was rather similar to Group II in age at immigration (means of 20 and 23 years), age at onset (39 and 33 years), and duration from immigration to onset (19 and 10 years). Group Ib (29 cases) was significantly different from Group II, with mean ages of 4 years at immigration and 40 years at onset, for a mean interval of some 35 years between immigration and onset. All onsets in Group Ib occurred after 1947. We concluded that the Group Ib cases had most probably acquired their MS in Australia. Immigrants from high MS risk countries, including UKI, were modest in number before 1947, but some 770,000 entered from 1947-1981. They may have been the source of MS for the Group Ib migrants.