Infant Neurobehavior Following Prenatal Exposure to Methadone or Buprenorphine: Results From the Neonatal Intensive Care Unit Network Neurobehavioral Scale
Infant Neurobehavior Following Prenatal Exposure to Methadone or Buprenorphine: Results From the Neonatal Intensive Care Unit Network Neurobehavioral Scale
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DOI：
10.3109/10826084.2010.484474
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发表时间：
2010-11-01
影响因子：
2
通讯作者：
Jansson, Lauren M.
中科院分区：
文献类型：
--
作者：
Jones, Hendree E.;O'Grady, Kevin E.;Jansson, Lauren M.
本研究检查了产前接触美沙酮 (n = 11) 或丁丙诺啡 (n = 10) 的新生儿的神经行为功能，这些新生儿在产后第 3、5、7、10 和 14 天接受了新生儿重症监护病房网络神经行为量表 (NNNS) 检查。线性混合模型分析表明，随着时间的推移，不同药物的唤醒和兴奋性 NNNS 评分显示出显着差异。与不需要药物治疗新生儿戒断综合征 (NAS) 的新生儿相比，接受 NAS 药物治疗的新生儿随着时间的推移，在运动质量、兴奋性和嗜睡方面表现出差异。结果表明，随着时间的推移，NNNS 可能会检测到产前接触美沙酮或丁丙诺啡的新生儿与接受或未接受 NAS 药物治疗的新生儿之间的细微差异。
This study examined the neurobehavioral functioning of neonates prenatally exposed to methadone (n = 11) or buprenorphine (n = 10), who underwent the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) examinations on days 3, 5, 7, 10, and 14 post-delivery. Linear mixed model analyses revealed that NNNS scores of arousal and excitability showed significant differences between medications over time. Compared to neonates who did not require medication to treat neonatal abstinence syndrome (NAS), neonates receiving pharmacotherapy for NAS showed differences over time in quality of movement, excitability, and lethargy. Results suggest the NNNS may detect subtle differences over time between both neonates prenatally exposed to methadone or buprenorphine and neonates pharmacologically treated or untreated for NAS.