Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women - A 20-year follow-up of the lipid research clinics prevalence study
Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women - A 20-year follow-up of the lipid research clinics prevalence study
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运动测试预测无症状妇女心血管疾病和全因死亡的能力--血脂研究诊所流行病研究 20 年的跟踪调查
DOI：
10.1001/jama.290.12.1600
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发表时间：
2003-09-24
影响因子：
120.7
通讯作者：
Blumenthal, RS
中科院分区：
文献类型：
--
作者：
Mora, S;Redberg, RF;Blumenthal, RS
背景运动测试对女性的价值受到质疑。目的确定运动测试对人群的预后价值：设计和设置来自脂质研究临床流行病学研究的近最大Bruce方案平板运动试验数据（1972-1976），随访至1995年。参与者：共有2994名无症状的北美妇女，年龄30 - 80岁，无已知心血管疾病。主要结果测量心血管和全因死亡率。结果在20年的随访中有427例（14%）死亡，其中147例为心血管疾病。低运动能力、低心率恢复（HRR）和未达到目标心率与全因和心血管死亡率增加独立相关。运动诱发ST段压低并没有增加心血管死亡风险（年龄校正的风险比，1.02; 95%可信区间[CI]，0.57-1.80; P=96）。运动能力每降低一次代谢当量（MET），年龄校正的心血管死亡危险比为1.20（95%CI，1.18-1.30; P
Context The value of exercise testing in women has been questioned.Objective To determine the prognostic value of exercise testing in a population: based cohort of asymptomatic women followed up for 20 years.Design and Setting Near-maximal Bruce-protocol treadmill test data from the Lipid Research Clinics Prevalence Study (1972-1976) with follow-up through 1995.Participants A total of 2994 asymptomatic North American women, aged 30 to 80 years, without known cardiovascular disease.Main Outcome Measures Cardiovascular and all-cause mortality.Results There were 427 (14%) deaths during 20 years of follow-up, of which 147 were due to cardiovascular causes. Low exercise capacity, low heart rate recovery (HRR), and not achieving target heart rate were independently associated with increased all-cause and cardiovascular mortality. There was no increased cardiovascular death risk for exercise-induced ST-segment depression (age-adjusted hazard ratio, 1.02; 95% confidence interval [CI], 0.57-1.80; P=96). The age-adjusted hazard ratio for cardiovascular death for every metabolic equivalent (MET) decrement in exercise capacity was 1.20 (95% Cl, 1.18-1.30; P