Effect of a short- and long-term treatment with Ginkgo biloba extract on Amyloid Precursor Protein Levels in a transgenic mouse model relevant to Alzheimer's disease
Effect of a short- and long-term treatment with Ginkgo biloba extract on Amyloid Precursor Protein Levels in a transgenic mouse model relevant to Alzheimer's disease
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DOI：
10.1016/j.abb.2008.10.032
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发表时间：
2009-01-15
影响因子：
3.9
通讯作者：
Cermak, Rainer
中科院分区：
文献类型：
--
作者：
Augustin, Sabine;Rimbach, Gerald;Cermak, Rainer
多项临床试验报告了银杏叶提取物 EGb761 在预防和治疗包括阿尔茨海默病 (AD) 在内的认知障碍方面的有益作用。本长期喂养试验的目的是研究膳食 EGb761 对人类 APP (Tg2576) 转基因小鼠的淀粉样前体蛋白 (APP) 代谢的影响。 Tg2576 小鼠分别用含有和不含 EGb761 的饮食（300 mg/kg 饮食）喂养 1 个月和 16 个月。与对照组相比，EGb761 长期治疗（16 个月）显着降低了皮质中人类 APP 蛋白水平约 50%，但海马体中却没有。然而，年轻小鼠中的 APP 水平不受 EGb761 的影响。目前的数据表明，APP 似乎是 EGb761 的所有重要分子靶标，与银杏叶治疗的持续时间和/或动物的年龄无关。 EGb761 的潜在神经保护特性可能至少部分与其 APP 降低活性有关。 (C) 2008 年，爱思唯尔公司出版。
Several Clinical trials have reported beneficial effects of the Ginkgo biloba extract EGb761 in the prevention and therapy of cognitive disorders including Alzheimer's disease (AD). The aim of the present long-term feeding trial Was to Study the impact of dietary EGb761 on Amyloid precursor protein (APP) metabolism in mice transgenic for human APP (Tg2576). Tg2576 mice were fed diets with and Without EGb761 (300 mg/kg diet) for I and 16 months, respectively. Long-term treatment (16 months) with EGb761 significantly lowered human APP protein levels by similar to 50% as compared to controls in the cortex but not in the hippocampus. However, APP levels were not affected by EGb761 in young mice. Current data indicate that APP seems to be all important molecular target of EGb761 ill relation to the duration of the Ginkgo biloba treatment and/or the age of the animals. Potential neuroprotective properties of EGb761 may be, at least partly, related to its APP lowering activity. (C) 2008 Published by Elsevier Inc.