The role of serum macrophage migration inhibitory factor in preoperative prediction of chronic rhinosinusitis with nasal polyps endotypes
The role of serum macrophage migration inhibitory factor in preoperative prediction of chronic rhinosinusitis with nasal polyps endotypes
复制标题
血清巨噬细胞迁移抑制因子在鼻息肉内型慢性鼻窦炎术前预测中的作用
DOI：
10.1016/j.intimp.2021.108084
复制
发表时间：
2021
影响因子：
5.6
通讯作者：
Xie Zhihai
中科院分区：
文献类型：
--
作者：
Yuan Xuan;Xie Shaobing;Jing Qiancheng;She Yongchuan;Jiang Weihong;Zhang Hua;Xie Zhihai
慢性鼻窦炎伴鼻息肉（CRSwNP）是一种高度异质性的疾病，可分为嗜酸性粒细胞性CRSwNP（eCRSwNP）和非嗜酸性粒细胞性CRSwNP（neCRSwNP）。探索有效的生物标志物来区分内型对于个体化治疗是重要的。本研究旨在评估血清MIF在CRSwNP内型中的预测价值。方法120例CRSwNP患者（包括51例eCRSwNP和69例neCRSwNP）、40例慢性鼻窦炎无鼻息肉（CRSsNP）患者和40例健康对照（HC）。酶联免疫吸附试验（ELISA）测定血清MIF水平。分析患者的临床变量与血清MIF的相关性。结果CRSwNP组血清MIF水平显著高于CRSsNP组和HC组（P <0.0 0 1），eCRSwNP组血清MIF水平显著高于neCRSwNP组（P = 0.0 0 6）。血清MIF水平升高与血嗜酸性粒细胞（B-EOS）计数显著相关（r = 0.411，P < 0.001），B-EOS百分比（r = 0.377，P < 0.001），视觉模拟量表评分CRSwNP组与组织嗜酸性粒细胞（T-EOS）计数（r = 0.204，P = 0.025）、T-EOS百分比（r = 0.705，P < 0.001）、T-EOS百分比（r = 0.671，P < 0.001）相关。ROC曲线显示血清MIF对CRSwNP内型有良好的预测作用（曲线下面积= 0.925，P < 0.001）。多变量回归分析表明，血清MIF是一个独立的因素与CRSwNP endotyps.ConclusionsThis是第一个研究确定血清MIF作为一个可能的特异性生物标志物术前区分CRSwNP endotypes。此外，血清MIF水平被发现与粘膜嗜酸性粒细胞浸润的程度密切相关。
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a highly heterogeneous disease and can be categorized into eosinophilic CRSwNP (eCRSwNP) and non-eosinophilic CRSwNP (neCRSwNP). Exploring effective biomarkers to distinguish endotypes is important for personalized therapies. The present study aims to evaluate the predictive value of serum MIF in CRSwNP endotypes.MethodsOne hundred and twenty CRSwNP patients, including 51 eCRSwNP and 69 neCRSwNP, 40 chronic rhinosinusitis without nasal polyps (CRSsNP) patients and 40 healthy controls (HC) were enrolled. Serum MIF levels were determined by enzyme-linked immunosorbent assay (ELISA). The patients’ clinical variables were analyzed for correlations with serum MIF. Receiver operating characteristic (ROC) curve and multivariate analysis were utilized to assess the predictive value of serum MIF in CRSwNP endotypes.ResultsThe serum MIF levels were significantly higher in CRSwNP group than CRSsNP group and HC group (P < 0.001), and the serum MIF levels were increased in eCRSwNP compared to neCRSwNP group (P = 0.006). Elevated serum MIF levels were significantly correlated with blood eosinophil (B-EOS) count (r = 0.411, P < 0.001), B-EOS percentage (r = 0.377, P < 0.001), visual analog scale score (r = 0.204, P = 0.025), tissue eosinophil (T-EOS) count (r = 0.705, P < 0.001) and T-EOS percentage (r = 0.671, P < 0.001) in CRSwNP patients. ROC curve demonstrated that serum MIF exhibited good preoperative prediction in CRSwNP endotypes (area under the curve = 0.925, P < 0.001). Multivariate regression analysis showed that serum MIF was an independent factor associated with CRSwNP endotypes.ConclusionsThis was the first study identifying serum MIF as a possible specific biomarker for preoperatively distinguishing CRSwNP endotypes. Furthermore, the serum MIF levels were found to be closely associated with the degree of mucosal eosinophil infiltration.