Micro-CT: Technology and applications for assessing bone structure
Micro-CT: Technology and applications for assessing bone structure
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DOI：
10.1007/s001170050497
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发表时间：
1999-03-01
期刊：
影响因子：
--
通讯作者：
Kalender, W
中科院分区：
文献类型：
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作者：
Engelke, K;Karolczak, M;Kalender, W
骨的强度和抗骨折性由骨小梁网和皮质壳的结构决定。虽然标准的2D技术，如组织形态测量不足以评估小梁网络的3D性质，但可以使用新的成像模式mu CT采集该网络的各向同性3D数据集。然而，到目前为止，所生成的数据集的定量分析，特别是描述骨骼结构的适当参数的提取，还没有最终解决。在这篇文章中，我们描述的技术和应用的mu CT系统在骨科领域的相关。在这种情况下，当前mu CT系统的最重要的技术特征是：1。空间分辨率可达5-10 μ m。2.最大样品尺寸与所需分辨率的关系约为1000倍，即10 μ m的分辨率将最大样品尺寸限制为约1 cm。3. mu CT系统的扫描时间从几分钟到几小时不等。目前mu CT系统在骨科的应用可以确定为五个领域：1.搜索表征3D小梁结构的参数。2.应用有限元模型确定生化能力的结构参数。3.在临床前试验中使用mu CT来研究药物在小动物中的作用.高分辨率活体成像系统分析方法的验证。5.建模和重塑过程的3D量化。
The strength and fracture resistance of bone is determined by the structure of the trabecular network and the cortical shell. While standard 2D techniques like histomorphometry are inadequate to assess the 3D nature of the trabecular network, isotropic 3D datasets of this network can be acquired with the new imaging modality of mu CT. However, so far the quantitative analysis of the generated datasets, in particular the extraction of appropriate parameters describing the bone structure, has not been finally solved. In this article we describe the technology and applications of mu CT systems relevant in the field of osteology. The most im portant technical features of current mu CT systems in this context are: 1. A spatial resolution down to 5-10 mu m can be achieved. 2. The maximum sample size is related to the desired resolution by a factor of approximately 1000, that is, a resolution of 10 mu m limits the maximum sample size to approximately 1 cm. 3. Scan times for mu CT systems vary between minutes and hours.Currently five areas for the application of mu CT systems in osteology can be identified:1. The search of parameters characterizing the 3D trabecular structure. 2. The application of finite element models to determine the biochemical competence of the structural parameters. 3.The use of mu CT in preclinical trials to study drug effects in small animals.4. The validation of analysis methods used in high-resolution in-vivo imaging systems. 5. The 3D quantification of modeling and remodeling processes.